Synthesis of novel isoxazole ring containing quinazoline derivatives and in vitro inhibitory activity against ptp alpha and ptp epsilon
文献类型：期刊论文
| 作者 | Yong Jian-Ping1,2; Haji, Akber Aisa1 |
| 刊名 | Chinese journal of organic chemistry
 |
| 出版日期 | 2008-07-01 |
| 卷号 | 28期号:7页码:1204-1208 |
| 关键词 | 7-nitro-4-chrolo-quinazoline 3-(substituted-phenyl)-isoxazole-5-methylamine 3-(substituted-phenyl)-isoxazole-5-methylamino-4(3h)-quinazoline derivative Inhibitory activity against ptp alpha Ptp epsilon |
| ISSN号 | 0253-2786 |
| 通讯作者 | Yong jian-ping() |
| 英文摘要 | 7-nitro-4-chrolo-quinazoline (4) was synthesized by two-step reactions using 4-nitro-2-aminobenezic acid and formamidine acetate as starting materials. and then, 3-(substituted-phenyl)isoxazole-5-methylamine derivatives 5a similar to 5e were synthesized by synthesizing substituted benaldehyde oxime, [3+2] dipolar cycloaddition reaction with propargyl alcohol, then acylation with methanesulfonyl chloride, substitution with nan(3) and reduction with zn/nh(4)cl. subsequently, 3-(substituted-phenyl)isoxazole-5-methylamino-4(3h)-quinazoline derivatives 6a similar to 6e were obtained by solid-grinding 5a similar to 5e and 4 under the basic al(2)o(3) at room temperature. their structures were confirmed by ir, hnmr and esi-ms spectra. the compounds 6a, 6c and 6d were assayed in vitro activity against ptp alpha, ptp epsilon, and showed that the tested compounds had no notable inhibitory activity in the concentration of 20 mu g/ml. |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000258257200009 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2384727 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yong Jian-Ping |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yong Jian-Ping,Haji, Akber Aisa. Synthesis of novel isoxazole ring containing quinazoline derivatives and in vitro inhibitory activity against ptp alpha and ptp epsilon[J]. Chinese journal of organic chemistry,2008,28(7):1204-1208. |
| APA | Yong Jian-Ping,&Haji, Akber Aisa.(2008).Synthesis of novel isoxazole ring containing quinazoline derivatives and in vitro inhibitory activity against ptp alpha and ptp epsilon.Chinese journal of organic chemistry,28(7),1204-1208. |
| MLA | Yong Jian-Ping,et al."Synthesis of novel isoxazole ring containing quinazoline derivatives and in vitro inhibitory activity against ptp alpha and ptp epsilon".Chinese journal of organic chemistry 28.7(2008):1204-1208. |
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来源：中国科学院大学
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