Preparation the key intermediate of angiotensin-converting enzyme (ace) inhibitors: high enantioselective production of ethyl (r)-2-hydroxy-4-phenylbutyrate with candida boidinii cioc21
文献类型：期刊论文
| 作者 | Chen, Yongzheng1,2,3; Lin, Hui1,2,3; Xu, Xiaoying1,2; Xia, Shiwen1,2; Wang, Lixin1,2 |
| 刊名 | Advanced synthesis & catalysis
 |
| 出版日期 | 2008-02-01 |
| 卷号 | 350期号:3页码:426-430 |
| 关键词 | Ace inhibitors Bioreduction Candida boidinii Ethyl (r)-2-hydroxy-4-phenylbutyrate Saccharomyces cerevisiae |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.200700420 |
| 通讯作者 | Xia, shiwen(swxia2008@hotmail.com) |
| 英文摘要 | Forty microorganisms belonging to different taxonomical groups were used to catalyze the enantioselective reduction of ethyl 2-oxophenylbutyrate to afford the corresponding ethyl 2-hydroxy-4-phenylbutyrate. several microorganisms led to over 99% ee of ethyl (s)-2-hydroxy-4-phenylbutyrate. especially, we firstly found that the candida boidinii cioc21 could be effectively used for the enantioselective preparation the ethyl (r)-2-hydroxy-4-phenylbutyrate in pure aqueous medium with 99% ee, a key intermediate in the production of angiotensin-converting enzyme (ace) inhibitors. |
| WOS关键词 | ASYMMETRIC REDUCTION ; ALPHA-KETOESTERS ; GREEN CHEMISTRY ; DEHYDROGENASE ; ESTER ; HYDROGENATION ; BIOREDUCTION ; DERIVATIVES ; RESOLUTION ; KETONES |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Applied ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000253600600015 |
| 出版者 | WILEY-BLACKWELL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2385062 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xia, Shiwen |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Union Lab Asymmetr Synth, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yongzheng,Lin, Hui,Xu, Xiaoying,et al. Preparation the key intermediate of angiotensin-converting enzyme (ace) inhibitors: high enantioselective production of ethyl (r)-2-hydroxy-4-phenylbutyrate with candida boidinii cioc21[J]. Advanced synthesis & catalysis,2008,350(3):426-430. |
| APA | Chen, Yongzheng,Lin, Hui,Xu, Xiaoying,Xia, Shiwen,&Wang, Lixin.(2008).Preparation the key intermediate of angiotensin-converting enzyme (ace) inhibitors: high enantioselective production of ethyl (r)-2-hydroxy-4-phenylbutyrate with candida boidinii cioc21.Advanced synthesis & catalysis,350(3),426-430. |
| MLA | Chen, Yongzheng,et al."Preparation the key intermediate of angiotensin-converting enzyme (ace) inhibitors: high enantioselective production of ethyl (r)-2-hydroxy-4-phenylbutyrate with candida boidinii cioc21".Advanced synthesis & catalysis 350.3(2008):426-430. |
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来源：中国科学院大学
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