On the nature of human housekeeping genes
文献类型：期刊论文
| 作者 | Zhu, Jiang1,2; He, Fuhong1,2; Hu, Songnian1; Yu, Jun1 |
| 刊名 | Trends in genetics
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 24期号:10页码:481-484 |
| ISSN号 | 0168-9525 |
| DOI | 10.1016/j.tig.2008.08.004 |
| 通讯作者 | Yu, jun(junyu@big.ac.cn) |
| 英文摘要 | Using a collection of expressed sequence tag (est) data, we re-evaluated the correlation of tissue specificity with genomic structure, phyletic age, evolutionary rate and promoter architecture of human genes. we found that housekeeping genes are less compact and older than tissue-specific genes, and they evolve more slowly in terms of both coding and core promoter sequences. housekeeping genes primarily use cpg-dependent core promoters, whereas the majority of tissue-specific genes possess neither cpg-islands nor tata-boxes in their core promoters. |
| WOS关键词 | HIGHLY EXPRESSED GENES ; II CORE PROMOTER ; TISSUE-SPECIFICITY ; CODON USAGE ; GENOME-WIDE ; SELECTION ; EVOLUTION ; DROSOPHILA ; COMPACT ; DESIGN |
| WOS研究方向 | Genetics & Heredity |
| WOS类目 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000260756300003 |
| 出版者 | ELSEVIER SCIENCE LONDON |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2385100 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Jun |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Jiang,He, Fuhong,Hu, Songnian,et al. On the nature of human housekeeping genes[J]. Trends in genetics,2008,24(10):481-484. |
| APA | Zhu, Jiang,He, Fuhong,Hu, Songnian,&Yu, Jun.(2008).On the nature of human housekeeping genes.Trends in genetics,24(10),481-484. |
| MLA | Zhu, Jiang,et al."On the nature of human housekeeping genes".Trends in genetics 24.10(2008):481-484. |
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来源：中国科学院大学
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