Antimicrobial effect by extracts of rhizome of alpinia officinarum hance may relate to its inhibition of beta-ketoacyl-acp reductase
文献类型：期刊论文
| 作者 | Huang, Hui; Wu, Dan; Tian, Wei-Xi; Ma, Xiao-Feng; Wu, Xiao-Dong |
| 刊名 | Journal of enzyme inhibition and medicinal chemistry
 |
| 出版日期 | 2008 |
| 卷号 | 23期号:3页码:362-368 |
| ISSN号 | 1475-6366 |
| 关键词 | Galangal Beta-ketoacyl-acp reductase (fabg) Antibacterial Inhibition Kinetic |
| DOI | 10.1080/14756360701622099 |
| 通讯作者 | Wu, xiao-dong(wuxd@gucas.ac.cn) |
| 英文摘要 | Inhibitory effects on bacterial growth showed that 40% ethanol extract of galangal (rhizome of alpinia officinarum hance) can inhibit staphylococcus aureus, alpha-hemolytic streptococcus, beta-hemolytic streptococcus and streptococcus pneumoniae. beta-ketoacyl-acp reductase (fabg, ec.1.1.1.100) is a key enzyme in type ii fatty acid synthase system in bacteria and catalyzes beta-ketoacyl-acp reduction. the galangal extracts inhibited fabg with an ic(50) value of only 4.47 +/- 0.10 mu g/ml and is more potent than other previously published inhibitors. kinetics studies showed that the inhibition consisted of both reversible and irreversible inhibition. the extracts of galangal inhibit fabg in a competitive pattern against nadph. so far, no inhibitor has been reported to exhibit irreversible inhibition of fabg, whereas the galangal ethanol extract can inhibit fabg irreversibly. the irreversible inhibition presented two phases. it is probable that the galangal extract inhibit fabg, thereby displaying antibacterial ability. |
| WOS关键词 | FATTY-ACID SYNTHESIS ; ESCHERICHIA-COLI ; SYNTHASE ; FABG ; BIOSYNTHESIS ; GALANGAL ; TARGETS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal |
| 语种 | 英语 |
| 出版者 | INFORMA HEALTHCARE |
| WOS记录号 | WOS:000256753000011 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2385352 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wu, Xiao-Dong |
| 作者单位 | Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Hui,Wu, Dan,Tian, Wei-Xi,et al. Antimicrobial effect by extracts of rhizome of alpinia officinarum hance may relate to its inhibition of beta-ketoacyl-acp reductase[J]. Journal of enzyme inhibition and medicinal chemistry,2008,23(3):362-368. |
| APA | Huang, Hui,Wu, Dan,Tian, Wei-Xi,Ma, Xiao-Feng,&Wu, Xiao-Dong.(2008).Antimicrobial effect by extracts of rhizome of alpinia officinarum hance may relate to its inhibition of beta-ketoacyl-acp reductase.Journal of enzyme inhibition and medicinal chemistry,23(3),362-368. |
| MLA | Huang, Hui,et al."Antimicrobial effect by extracts of rhizome of alpinia officinarum hance may relate to its inhibition of beta-ketoacyl-acp reductase".Journal of enzyme inhibition and medicinal chemistry 23.3(2008):362-368. |
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来源：中国科学院大学
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