Studies on the acute biochemical effects of nd(no3)(3) by nuclear magnetic resonance-based metabonomics
文献类型：期刊论文
| 作者 | Liao Pei-Qiu1,2; Zhang Xiao-Yu3; Wei, Lai1,2; Li Wei-Sheng1,2; Wu Yi-Jie1; Li Xiao-Jing1; Ni Jia-Zuan1; Pei Feng-Kui1 |
| 刊名 | Chinese journal of analytical chemistry
 |
| 出版日期 | 2008-04-01 |
| 卷号 | 36期号:4页码:426-432 |
| 关键词 | Neodymium nitrate Biofluids Nuclear magnetic resonance Biochemical effects Pattern recognition Metabonomics |
| ISSN号 | 0253-3820 |
| 通讯作者 | Pei feng-kui(peifk@ciac.jl.cn) |
| 英文摘要 | The biochemical effects of nd(no3)(3) was studied by nmr-based metabonomics. male wistar rats were administrated intraperitoneally with nd (no3)(3) at doses of 2, 10 and 50 mg/kg body weight. urine was collected over a 48-h period after dosing and serum was collected after 48 h. h-1 nmr spectra of biofluids (urine and serum) were analyzed by pattern recognition using principal components analysis. the studies showed that there was a dose-related biochemical effects of nd (no3)(3) treatment. the liver and kidney (renal. tubular and renal papilla) damage induced by nd (no3)(3) was characterized by the variations of many endogenous metabolites, such as citrate, creatinine, n-trimethyl dioxide, dimethyl amine, dimethyl glycine, lactate, taurine and glucose. the nmr-based metabonomics can be applied to study the biochemical effects or toxicities of other compounds. |
| WOS关键词 | INDUCED HEPATOTOXICITY ; PATTERN-RECOGNITION ; ACUTE TOXICITY ; SPECTROSCOPY ; URINE ; RATS ; MODEL ; CLASSIFICATION ; COMPOUND |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000256066500002 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2385456 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Pei Feng-Kui |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Yanshan Univ, Coll Environm & Chem Engn, Dept Biol Engn, Qinhuangdao 066004, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao Pei-Qiu,Zhang Xiao-Yu,Wei, Lai,et al. Studies on the acute biochemical effects of nd(no3)(3) by nuclear magnetic resonance-based metabonomics[J]. Chinese journal of analytical chemistry,2008,36(4):426-432. |
| APA | Liao Pei-Qiu.,Zhang Xiao-Yu.,Wei, Lai.,Li Wei-Sheng.,Wu Yi-Jie.,...&Pei Feng-Kui.(2008).Studies on the acute biochemical effects of nd(no3)(3) by nuclear magnetic resonance-based metabonomics.Chinese journal of analytical chemistry,36(4),426-432. |
| MLA | Liao Pei-Qiu,et al."Studies on the acute biochemical effects of nd(no3)(3) by nuclear magnetic resonance-based metabonomics".Chinese journal of analytical chemistry 36.4(2008):426-432. |
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来源：中国科学院大学
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