Salk/salr, a two-component signal transduction system, is essential for full virulence of highly invasive streptococcus suis serotype 2
文献类型：期刊论文
| 作者 | Li, Ming1,2; Wang, Changjun2; Feng, Youjun3,5; Pan, Xiuzhen2; Cheng, Gong2; Wang, Jing2; Ge, Junchao2; Zheng, Feng2; Cao, Min2; Dong, Yaqing2 |
| 刊名 | Plos one
 |
| 出版日期 | 2008-05-07 |
| 卷号 | 3期号:5页码:12 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0002080 |
| 通讯作者 | Li, ming() |
| 英文摘要 | Background: streptococcus suis serotype 2 (s. suis 2, ss2) has evolved into a highly infectious entity, which caused the two recent large-scale outbreaks of human ss2 epidemic in china, and is characterized by a toxic shock-like syndrome. however, the molecular pathogenesis of this new emerging pathogen is still poorly understood. methodology/principal findings: 89k is a newly predicted pathogenicity island (pai) which is specific to chinese epidemic strains isolated from these two ss2 outbreaks. further bioinformatics analysis revealed a unique two-component signal transduction system (tcsts) located in the candidate 89k pai, which is orthologous to the salk/salr regulatory system of streptococcus salivarius. knockout of salkr eliminated the lethality of ss2 in experimental infection of piglets. functional complementation of salkr into the isogenic mutant dsalkr restored its soaring pathogenicity. colonization experiments showed that the dsalkr mutant could not colonize any susceptible tissue of piglets when administered alone. bactericidal assays demonstrated that resistance of the mutant to polymorphonuclear leukocyte (pmn)-mediated killing was greatly decreased. expression microarray analysis exhibited a transcription profile alteration of 26 various genes down-regulated in the dsalkr mutant. conclusions/significance: these findings suggest that salk/salr is requisite for the full virulence of ethnic chinese isolates of highly pathogenic ss2, thus providing experimental evidence for the validity of this bioinformatically predicted pai. |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| WOS记录号 | WOS:000261642400004 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2385556 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Ming |
| 作者单位 | 1.Third Mil Med Univ, Dept Microbiol, Chongqing, Peoples R China 2.Res Inst Med Nanjing Command, Dept Epidemiol, Nanjing, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, Ctr Mol Immunol, Beijing, Peoples R China 4.S China Univ Technol, Sch Biosci & Bioengn, Provincial Key Lab Biotechnol, Guangzhou, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ming,Wang, Changjun,Feng, Youjun,et al. Salk/salr, a two-component signal transduction system, is essential for full virulence of highly invasive streptococcus suis serotype 2[J]. Plos one,2008,3(5):12. |
| APA | Li, Ming.,Wang, Changjun.,Feng, Youjun.,Pan, Xiuzhen.,Cheng, Gong.,...&Tang, Jiaqi.(2008).Salk/salr, a two-component signal transduction system, is essential for full virulence of highly invasive streptococcus suis serotype 2.Plos one,3(5),12. |
| MLA | Li, Ming,et al."Salk/salr, a two-component signal transduction system, is essential for full virulence of highly invasive streptococcus suis serotype 2".Plos one 3.5(2008):12. |
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来源：中国科学院大学
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