Serine palmitoyltransferase, a key enzyme for de novo synthesis of sphingolipids, is essential for male gametophyte development in arabidopsis
文献类型：期刊论文
| 作者 | Teng, Chong1,2,3; Dong, Haili1,2,3; Shi, Lihua1,2,3; Deng, Yan1,2,3; Mu, Jinye1,2,3; Zhang, Jian1,2; Yang, Xiaohui1,2; Zuo, Jianru1,2 |
| 刊名 | Plant physiology
 |
| 出版日期 | 2008-03-01 |
| 卷号 | 146期号:3页码:1322-1332 |
| ISSN号 | 0032-0889 |
| DOI | 10.1104/pp.107.113506 |
| 通讯作者 | Zuo, jianru(jrzuo@genetics.ac.cn) |
| 英文摘要 | Sphingolipids are important signaling molecules involved in various cellular activities. de novo sphingolipid synthesis is initiated by a rate-limiting enzyme, serine palmitoyltransferase (spt), a heterodimer consisting of long-chain base1 (lcb1) and lcb2 subunits. a mutation in the arabidopsis thaliana lcb1 gene, lcb1-1, was found to cause embryo lethality. however, the underpinning molecular and cellular mechanisms remain largely unclear. here, we report the identification of the fumonisin b 1 resistant11-2 (fbr11-2) mutant, an allele of lcb1-1. the fbr11-2 mutation, most likely an allele stronger than lcb1-1, was transmitted only through female gametophytes and caused the formation of abortive microspores. during the second pollen mitosis, fbr11-2 initiated apoptotic cell death in binucleated microspores characteristic of nuclear dna fragmentation, followed by cytoplasm shrinkage and organelle degeneration at the trinucleated stage. in addition, a double mutant with t-dna insertions in two homologous lcb2 genes showed a phenotype similar to fbr11-2. consistent with these observations, the fbr11/lcb1 expression was confined in microspores during microgametogenesis. these results suggest that spt-modulated programmed cell death plays an important role in the regulation of male gametophyte development. |
| WOS关键词 | PROGRAMMED CELL-DEATH ; PLANT SPHINGOLIPIDS ; POLLEN MUTANTS ; GENE ENCODES ; THALIANA ; BIOSYNTHESIS ; METABOLISM ; DIVISION ; SUBUNIT ; PROTEIN |
| WOS研究方向 | Plant Sciences |
| WOS类目 | Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000256412200053 |
| 出版者 | AMER SOC PLANT BIOLOGISTS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2385579 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zuo, Jianru |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Genet & Dev Biol, Natl Plant Gene Res Ctr, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Teng, Chong,Dong, Haili,Shi, Lihua,et al. Serine palmitoyltransferase, a key enzyme for de novo synthesis of sphingolipids, is essential for male gametophyte development in arabidopsis[J]. Plant physiology,2008,146(3):1322-1332. |
| APA | Teng, Chong.,Dong, Haili.,Shi, Lihua.,Deng, Yan.,Mu, Jinye.,...&Zuo, Jianru.(2008).Serine palmitoyltransferase, a key enzyme for de novo synthesis of sphingolipids, is essential for male gametophyte development in arabidopsis.Plant physiology,146(3),1322-1332. |
| MLA | Teng, Chong,et al."Serine palmitoyltransferase, a key enzyme for de novo synthesis of sphingolipids, is essential for male gametophyte development in arabidopsis".Plant physiology 146.3(2008):1322-1332. |
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来源：中国科学院大学
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