UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii
文献类型：期刊论文
| 作者 | Zhou, Da-Yong2; Zhang, Xiu-Li1; Xu, Qing1; Xue, Xing-Ya1; Zhang, Fei-Fang1; Liang, Xin-Miao1 |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2009-08-15 |
| 卷号 | 50期号:1页码:2-8 |
| 关键词 | UPLC Q-TOFMS/MS PMFs Fructus aurantii Rapid identification Mass spectrometric fingerprint |
| 产权排序 | 2;2 |
| 通讯作者 | 张秀莉 |
| 英文摘要 | polymethoxylated flavones (pmfs), as potential cancer chemopreventive agents, are widely distributed in citrus genus. in this study, a selected ion monitoring-tandem mass (sim-ms/ms) method for the rapid identification of pmfs in fructus aurantii (e aurantii) with ultra-performance liquid chromatography (uplc) coupled to quadrupole, hybrid orthogonal acceleration time-of-flight tandem mass spectrometer (q-tofms/ms) was proposed. the ms data for candidates, containing accurate mass and isotopic patterns for both precursors and their fragment ions, were acquired selectively. based on the ms data, the mass spectrometric fingerprint (msfp) for candidates, consisting of chemical formula and dissociation pattern, was determined. comparing the msfps of the observed compounds with the diagnostic msfp of the species, 44 pmfs were tentatively identified. the method was validated by tangeretin and sinensetin, two representative compounds of pmfs, and was considered to be suitable for the rapid screening of pmfs in crude and partially purified samples. (c) 2009 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | squamous-cell carcinoma ; liquid-chromatography ; mass-spectrometry |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000266683700001 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/102617]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Dalian Polytech Univ, Coll Biol & Food Technol, Dalian 116034, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Da-Yong,Zhang, Xiu-Li,Xu, Qing,et al. UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii[J]. journal of pharmaceutical and biomedical analysis,2009,50(1):2-8. |
| APA | Zhou, Da-Yong,Zhang, Xiu-Li,Xu, Qing,Xue, Xing-Ya,Zhang, Fei-Fang,&Liang, Xin-Miao.(2009).UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii.journal of pharmaceutical and biomedical analysis,50(1),2-8. |
| MLA | Zhou, Da-Yong,et al."UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii".journal of pharmaceutical and biomedical analysis 50.1(2009):2-8. |
入库方式： OAI收割
来源：大连化学物理研究所
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