Quality and safety of Chinese herbal medicines guided by a systems biology perspective
文献类型：期刊论文
| 作者 | Wang, Jiangshan3,4,7; van der Heijden, Rob4; Spruit, Shannon1,2; Hankermeier, Thomas4; Chan, Kelvin5,6; van der Greef, Jan1,2,4,7; Xu, Guowang3,7; Wang, Mei1,2,7 |
| 刊名 | journal of ethnopharmacology
 |
| 出版日期 | 2009-10-29 |
| 卷号 | 126期号:1页码:31-41 |
| 关键词 | Chinese materia medica Systems biology Systems toxicology Metabolomics Aconitum roots |
| 产权排序 | 1;1 |
| 通讯作者 | 许国旺 |
| 英文摘要 | chinese herbal medicines, often referred as chinese materia medica (cmm), are comprised of a complex multicomponent nature. the activities are aimed at the system level via interactions with a multitude of targets in the human body. this review aims at the toxicity aspects of cmm and its preparations at the different steps of production; harvesting, processing and the final formulation. the historic perspective and today's issues of the safety of cmm are introduced briefly, followed by the descriptions of the toxic cmm in the current chinese pharmacopoeia (2005). subsequently, several aspects of safety are illustrated using a typical example of a toxic cmm, aconitum roots, and some recent findings of our own research are included to illustrate that proper processing and multi-herbs formulation can reduce the level of toxic components. this also explains that in cmm, some herbs, such as aconitum, ephedra species are never used as single herb for intervention and that aconite is only used when it is processed and in combination with specific matched other herbs. the formulation principle of multi-herbs intervention strategy is a systems approach for the treatment and prevention of disease. in this light, the role of systems toxicology in the safety and quality of chinese herbal medicine is proposed as a promising method. moreover the principles of practiced-based and evidence-based research are discussed from a symbiotic perspective. (c) 2009 elsevier ireland ltd. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | plant sciences ; chemistry, medicinal ; integrative & complementary medicine ; pharmacology & pharmacy |
| 研究领域[WOS] | plant sciences ; pharmacology & pharmacy ; integrative & complementary medicine |
| 关键词[WOS] | severe myoclonic epilepsy ; mass-spectrometry ; drug safety ; aristolochic acid ; field-desorption ; aconitum ; toxicity ; alkaloids ; pharmacology ; mutations |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000271790800003 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/102729]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.SU BioMed, NL-3700 AJ Zeist, Netherlands 2.TNO, Qual Life, NL-3700 AJ Zeist, Netherlands 3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 4.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, NL-2300 RA Leiden, Netherlands 5.Wolverhampton Univ, Sch Appl Sci, Res Inst Healthcare Sci, Wolverhampton WV1 1LY, England 6.Wolverhampton Univ, Dept Pharm, Wolverhampton WV1 1LY, England 7.Sino Dutch Ctr Prevent & Personalized Med, NL-3700 AJ Zeist, Netherlands |
| 推荐引用方式 GB/T 7714 | Wang, Jiangshan,van der Heijden, Rob,Spruit, Shannon,et al. Quality and safety of Chinese herbal medicines guided by a systems biology perspective[J]. journal of ethnopharmacology,2009,126(1):31-41. |
| APA | Wang, Jiangshan.,van der Heijden, Rob.,Spruit, Shannon.,Hankermeier, Thomas.,Chan, Kelvin.,...&Wang, Mei.(2009).Quality and safety of Chinese herbal medicines guided by a systems biology perspective.journal of ethnopharmacology,126(1),31-41. |
| MLA | Wang, Jiangshan,et al."Quality and safety of Chinese herbal medicines guided by a systems biology perspective".journal of ethnopharmacology 126.1(2009):31-41. |
入库方式： OAI收割
来源：大连化学物理研究所
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