中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Intravenous Fentanyl is Exhaled and the Concentration Fluctuates with Time

文献类型:期刊论文

作者Wang, H.1; Li, E. Y.1; Xu, G. W.2; Wang, C. S.1; Gong, Y. L.1; Li, P.1
刊名journal of international medical research
出版日期2009-07-01
卷号37期号:4页码:1158-1166
关键词FENTANYL OPIOID ANAESTHETICS PHARMACOKINETICS ELIMINATION EXHALATION
产权排序2;3
通讯作者李恩有
英文摘要previous studies have reported that fentanyl is eliminated predominantly by hepatic biotransformation, and that some is eliminated unchanged in urine and stools. no reports have described the elimination of fentanyl via the lungs. in this study, exhaled gas samples from eight anaesthetized patients undergoing cardiac surgery were analysed using solid-phase microextraction (spme) coupled with gas chromatography-mass spectrometry (gc-ms). results confirmed that fentanyl was exhaled by patients after intravenous administration, that the concentration of exhaled fentanyl fluctuated with time and peak concentrations were reached approximately 15 - 20 min after intravenous fentanyl administration. thus, in addition to hepatic biotransformation and elimination via urine and faeces, fentanyl is also eliminated unchanged by the lungs. the potential risk to operating theatre personnel from long-term exposure to low levels of exhaled anaesthetic agents following intravenous administration to patients during surgery warrants further research.
WOS标题词science & technology ; life sciences & biomedicine
类目[WOS]medicine, research & experimental ; pharmacology & pharmacy
研究领域[WOS]research & experimental medicine ; pharmacology & pharmacy
关键词[WOS]chromatography-mass spectrometry ; solid-phase microextraction ; human plasma ; gas ; alfentanil ; propofol ; anesthesiologists ; sufentanil ; addiction ; kinetics
收录类别SCI
原文出处false
语种英语
WOS记录号WOS:000271036300021
公开日期2010-11-30
源URL[http://159.226.238.44/handle/321008/102733]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
作者单位1.Harbin Med Univ, Dept Anaesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian, Liaoning, Peoples R China
推荐引用方式
GB/T 7714
Wang, H.,Li, E. Y.,Xu, G. W.,et al. Intravenous Fentanyl is Exhaled and the Concentration Fluctuates with Time[J]. journal of international medical research,2009,37(4):1158-1166.
APA Wang, H.,Li, E. Y.,Xu, G. W.,Wang, C. S.,Gong, Y. L.,&Li, P..(2009).Intravenous Fentanyl is Exhaled and the Concentration Fluctuates with Time.journal of international medical research,37(4),1158-1166.
MLA Wang, H.,et al."Intravenous Fentanyl is Exhaled and the Concentration Fluctuates with Time".journal of international medical research 37.4(2009):1158-1166.

入库方式: OAI收割

来源:大连化学物理研究所

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