Intravenous Fentanyl is Exhaled and the Concentration Fluctuates with Time
文献类型：期刊论文
| 作者 | Wang, H.1; Li, E. Y.1; Xu, G. W.2; Wang, C. S.1; Gong, Y. L.1; Li, P.1 |
| 刊名 | journal of international medical research
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 37期号:4页码:1158-1166 |
| 关键词 | FENTANYL OPIOID ANAESTHETICS PHARMACOKINETICS ELIMINATION EXHALATION |
| 产权排序 | 2;3 |
| 通讯作者 | 李恩有 |
| 英文摘要 | previous studies have reported that fentanyl is eliminated predominantly by hepatic biotransformation, and that some is eliminated unchanged in urine and stools. no reports have described the elimination of fentanyl via the lungs. in this study, exhaled gas samples from eight anaesthetized patients undergoing cardiac surgery were analysed using solid-phase microextraction (spme) coupled with gas chromatography-mass spectrometry (gc-ms). results confirmed that fentanyl was exhaled by patients after intravenous administration, that the concentration of exhaled fentanyl fluctuated with time and peak concentrations were reached approximately 15 - 20 min after intravenous fentanyl administration. thus, in addition to hepatic biotransformation and elimination via urine and faeces, fentanyl is also eliminated unchanged by the lungs. the potential risk to operating theatre personnel from long-term exposure to low levels of exhaled anaesthetic agents following intravenous administration to patients during surgery warrants further research. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | medicine, research & experimental ; pharmacology & pharmacy |
| 研究领域[WOS] | research & experimental medicine ; pharmacology & pharmacy |
| 关键词[WOS] | chromatography-mass spectrometry ; solid-phase microextraction ; human plasma ; gas ; alfentanil ; propofol ; anesthesiologists ; sufentanil ; addiction ; kinetics |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000271036300021 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/102733]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Harbin Med Univ, Dept Anaesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, H.,Li, E. Y.,Xu, G. W.,et al. Intravenous Fentanyl is Exhaled and the Concentration Fluctuates with Time[J]. journal of international medical research,2009,37(4):1158-1166. |
| APA | Wang, H.,Li, E. Y.,Xu, G. W.,Wang, C. S.,Gong, Y. L.,&Li, P..(2009).Intravenous Fentanyl is Exhaled and the Concentration Fluctuates with Time.journal of international medical research,37(4),1158-1166. |
| MLA | Wang, H.,et al."Intravenous Fentanyl is Exhaled and the Concentration Fluctuates with Time".journal of international medical research 37.4(2009):1158-1166. |
入库方式： OAI收割
来源：大连化学物理研究所
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