Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes
文献类型：期刊论文
| 作者 | Qiu, Yuqin1,2; Gao, Yunhua1; Hu, Kejia1,2; Li, Fang1 |
| 刊名 | Journal of controlled release
 |
| 出版日期 | 2008-07-14 |
| 卷号 | 129期号:2页码:144-150 |
| 关键词 | Microneedles Elastic liposomes Transdermal delivery Docetaxel |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2008.04.019 |
| 通讯作者 | Gao, yunhua(yhgao@mail.ipc.ac.cn) |
| 英文摘要 | A combination method of using microneedle pretreatment and elastic liposomes was developed to increase skin permeation of drugs with high molecular weight and poor water solubility docetaxel (dtx, mw = 807.9) was chosen as a model drug. dtx liposomal systems with and without elastic properties were prepared and characterized. the effect of the developed formulations on the permeation of dtx across both rat and porcine skin was investigated in vitro. the combination effect of microneedle pretreatment and elastic liposomes on the permeability of dtx was evaluated using porcine skin in vitro. the following results were obtained: (1) elastic liposomes loaded with dtx can enhance transdermal delivery of dtx without microneedle treatment. (2) an enhanced transdermal flux (1.3-1.4 mu g/cm(2)/h) for dtx from all liposomal formulations was observed after microneedle treatment. importantly, the lag time obtained following the application of elastic liposomes through microneedle-treated skin was decreased by nearly 70% compared with that obtained from conventional liposomes. these results suggest that the combination of elastic liposomes with microneedle pretreatment can be a useful method to increase skin permeation of drugs with high molecular weight and poor water solubility. (c) 2008 elsevier b.v. all rights reserved. |
| WOS关键词 | TRANSDERMAL DRUG-DELIVERY ; PERCUTANEOUS-ABSORPTION ; IN-VIVO ; MICROFABRICATED MICRONEEDLES ; ENCAPSULATED TETRACAINE ; TOPICAL ANESTHESIA ; LIPID VESICLES ; DOSAGE FORM ; PENETRATION ; TRANSPORT |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000257959400012 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2386257 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gao, Yunhua |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Yuqin,Gao, Yunhua,Hu, Kejia,et al. Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes[J]. Journal of controlled release,2008,129(2):144-150. |
| APA | Qiu, Yuqin,Gao, Yunhua,Hu, Kejia,&Li, Fang.(2008).Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes.Journal of controlled release,129(2),144-150. |
| MLA | Qiu, Yuqin,et al."Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes".Journal of controlled release 129.2(2008):144-150. |
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来源：中国科学院大学
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