Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes
文献类型：期刊论文
| 作者 | Wang, Ping1,2,3; Yin, Shanye1,2,3; Zhang, Zhenguo1,2,3; Xin, Dedong1,2; Hu, Landian1,2; Kong, Xiangyin1,2,4; Hurst, Laurence D.5 |
| 刊名 | Genome biology
 |
| 出版日期 | 2008 |
| 卷号 | 9期号:12页码:11 |
| ISSN号 | 1474-760X |
| DOI | 10.1186/gb-2008-9-12-r169 |
| 通讯作者 | Kong, xiangyin(xykong@sibs.ac.cn) |
| 英文摘要 | Background: there is increasing realization that regulation of genes is done partly at the rna level by sense-antisense binding. studies typically concentrate on the role of non-coding rnas in regulating coding rna. but the majority of transcripts in a cell are likely to be coding. is it possible that coding rna might regulate other coding rna by short perfect sense-antisense binding? here we compare all well-described human protein coding mrnas against all others to identify sites 1525 bp long that could potentially perfectly match sense-antisense. results: from 24,968 protein coding mrna refseq sequences, none failed to find at least one match in the transcriptome. by randomizations generating artificial transcripts matched for g+c content and length, we found that there are more such trans short sense-antisense pairs than expected. several further features are consistent with functionality of some of the putative matches. first, transcripts with more potential partners have lower expression levels, and the pair density of tissue specific genes is significantly higher than that of housekeeping genes. further, the single nucleotide polymorphism density is lower in short pairing regions than it is in flanking regions. we found no evidence that the sense-antisense pairing regions are associated with small rnas derived from the protein coding genes. conclusions: our results are consistent with the possibility of common short perfect sense-antisense pairing between transcripts of protein coding genes. |
| WOS关键词 | HUMAN GENOME ; SMALL RNAS ; EXPRESSION ; MESSENGER ; MICRORNAS ; SILENCE ; ALPHA |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000263074100008 |
| 出版者 | BIOMED CENTRAL LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2386331 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Kong, Xiangyin |
| 作者单位 | 1.Chinese Acad Sci, SIBS, Inst Hlth Sci, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Shanghai Jiao Tong Univ, Ruijin Hosp, State Key Lab Med Genom, Shanghai 200025, Peoples R China 5.Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England |
| 推荐引用方式 GB/T 7714 | Wang, Ping,Yin, Shanye,Zhang, Zhenguo,et al. Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes[J]. Genome biology,2008,9(12):11. |
| APA | Wang, Ping.,Yin, Shanye.,Zhang, Zhenguo.,Xin, Dedong.,Hu, Landian.,...&Hurst, Laurence D..(2008).Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes.Genome biology,9(12),11. |
| MLA | Wang, Ping,et al."Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes".Genome biology 9.12(2008):11. |
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来源：中国科学院大学
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