Genes of hippo signaling network act unconventionally in the control of germline proliferation in drosophila
文献类型：期刊论文
| 作者 | Sun, Shuguo1,2; Zhao, Shaowei1,2; Wang, Zhaohui1 |
| 刊名 | Developmental dynamics
 |
| 出版日期 | 2008 |
| 卷号 | 237期号:1页码:270-275 |
| 关键词 | Hippo Expanded Germline Proliferation Drosophila |
| ISSN号 | 1058-8388 |
| DOI | 10.1002/dvdy.21411 |
| 通讯作者 | Wang, zhaohui(zhwang@genetics.ac.cn) |
| 英文摘要 | Hippo pathway and its related genes are required for growth control in various somatic tissues. the mutations of hippo pathway components lead to tissue overgrowth cell-autonomously. surprisingly, when we generated germline mutant clones of hippo-network genes such as fat, expanded, hippo, salvador, and warts, we did not observe any overgrowth of these mutant cells. consistently, overexpression of the progrowth gene yorkie, which is normally inhibited by hippo signaling, did not lead to germline overgrowth either. in contrast to previous studies in epithelial tissues, these tumor suppressor genes are dispensable in germline cells for their proliferation control. furthermore, we demonstrate that expanded functions nonautonomously to regulate spermatogonial proliferation. it appears that expanded acts from the somatic support cells surrounding the germline to restrict spermatogonial amplification. developmental dynamics 237:270-275, 2008. (c) 2007 wiley-liss, inc. |
| WOS关键词 | TUMOR-SUPPRESSOR PATHWAY ; REGULATE CELL-PROLIFERATION ; PROMOTES APOPTOSIS ; EXPANDED FUNCTION ; PROTEIN-KINASE ; CYCLE EXIT ; ORGAN SIZE ; FAT ; GROWTH ; SPERMATOGENESIS |
| WOS研究方向 | Anatomy & Morphology ; Developmental Biology |
| WOS类目 | Anatomy & Morphology ; Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000252386300026 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2386464 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Zhaohui |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Shuguo,Zhao, Shaowei,Wang, Zhaohui. Genes of hippo signaling network act unconventionally in the control of germline proliferation in drosophila[J]. Developmental dynamics,2008,237(1):270-275. |
| APA | Sun, Shuguo,Zhao, Shaowei,&Wang, Zhaohui.(2008).Genes of hippo signaling network act unconventionally in the control of germline proliferation in drosophila.Developmental dynamics,237(1),270-275. |
| MLA | Sun, Shuguo,et al."Genes of hippo signaling network act unconventionally in the control of germline proliferation in drosophila".Developmental dynamics 237.1(2008):270-275. |
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来源：中国科学院大学
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