Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for beta-amyloid plaques in alzheimer's disease
文献类型：期刊论文
| 作者 | Zheng, Ming-Qiang1,2; Yin, Duan-Zhi1; Qiao, Jin-Ping3,4; Zhang, Lan1; Wang, Yong-Xian1 |
| 刊名 | Journal of fluorine chemistry
 |
| 出版日期 | 2008-03-01 |
| 卷号 | 129期号:3页码:210-216 |
| 关键词 | Alzheimer's disease F-n-me F-n,n-me [(18)f]o-fet-pib Pet |
| ISSN号 | 0022-1139 |
| DOI | 10.1016/j.jfluchem.2007.11.005 |
| 通讯作者 | Yin, duan-zhi(comingzeng@yahoo.com.cn) |
| 英文摘要 | [(11)c]2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole ([(11)c]pib) is a most potential pet tracer for detecting the beta-amyloid plaques in alzheimer's disease. here the syntheses of three fluorinated pib, namely 2-(4'-(methylamino)phenyl)-6-fluoroethoxybenzothiazole (o-fet-pib), 2-(4'-(methylamino)phenyl)-6-fluoro-benzothiazole (f-n-me) and 2-(4'-(dimethylamino)phenyl)-6-fluorobenzo-thiazole (f-n,n-me), and the radiosynthesis of one corresponding (18)f-labeled pib compound, [(18)f]o-fet-pib, as well as their in vitro/in vivo biological characters were reported. the structures of the products were confirmed by ir, (1)h nmr, ei/esi-ms, elemental analysis and hrms techniques. the radiolabeled product was characterized by radio-tlc and radio-hplc and purified by semi-preparative radio-hplc. the suitable biological characters showed these tracers were potential to be developed as probes for detecting beta-amyloid plaques in alzheimer's disease. (c) 2007 elsevier b.v. all rights reserved. |
| WOS关键词 | IMAGING AGENTS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Inorganic & Nuclear ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000254018900008 |
| 出版者 | ELSEVIER SCIENCE SA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2386562 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yin, Duan-Zhi |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Res Ctr Radiopharmaceut, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China 4.Univ Sci & Technol China, Sch Life Sci, Dept Neurobiol, Hefei 230027, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Ming-Qiang,Yin, Duan-Zhi,Qiao, Jin-Ping,et al. Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for beta-amyloid plaques in alzheimer's disease[J]. Journal of fluorine chemistry,2008,129(3):210-216. |
| APA | Zheng, Ming-Qiang,Yin, Duan-Zhi,Qiao, Jin-Ping,Zhang, Lan,&Wang, Yong-Xian.(2008).Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for beta-amyloid plaques in alzheimer's disease.Journal of fluorine chemistry,129(3),210-216. |
| MLA | Zheng, Ming-Qiang,et al."Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for beta-amyloid plaques in alzheimer's disease".Journal of fluorine chemistry 129.3(2008):210-216. |
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来源：中国科学院大学
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