中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for beta-amyloid plaques in alzheimer's disease

文献类型:期刊论文

作者Zheng, Ming-Qiang1,2; Yin, Duan-Zhi1; Qiao, Jin-Ping3,4; Zhang, Lan1; Wang, Yong-Xian1
刊名Journal of fluorine chemistry
出版日期2008-03-01
卷号129期号:3页码:210-216
关键词Alzheimer's disease F-n-me F-n,n-me [(18)f]o-fet-pib Pet
ISSN号0022-1139
DOI10.1016/j.jfluchem.2007.11.005
通讯作者Yin, duan-zhi(comingzeng@yahoo.com.cn)
英文摘要[(11)c]2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole ([(11)c]pib) is a most potential pet tracer for detecting the beta-amyloid plaques in alzheimer's disease. here the syntheses of three fluorinated pib, namely 2-(4'-(methylamino)phenyl)-6-fluoroethoxybenzothiazole (o-fet-pib), 2-(4'-(methylamino)phenyl)-6-fluoro-benzothiazole (f-n-me) and 2-(4'-(dimethylamino)phenyl)-6-fluorobenzo-thiazole (f-n,n-me), and the radiosynthesis of one corresponding (18)f-labeled pib compound, [(18)f]o-fet-pib, as well as their in vitro/in vivo biological characters were reported. the structures of the products were confirmed by ir, (1)h nmr, ei/esi-ms, elemental analysis and hrms techniques. the radiolabeled product was characterized by radio-tlc and radio-hplc and purified by semi-preparative radio-hplc. the suitable biological characters showed these tracers were potential to be developed as probes for detecting beta-amyloid plaques in alzheimer's disease. (c) 2007 elsevier b.v. all rights reserved.
WOS关键词IMAGING AGENTS
WOS研究方向Chemistry
WOS类目Chemistry, Inorganic & Nuclear ; Chemistry, Organic
语种英语
WOS记录号WOS:000254018900008
出版者ELSEVIER SCIENCE SA
URI标识http://www.irgrid.ac.cn/handle/1471x/2386562
专题中国科学院大学
通讯作者Yin, Duan-Zhi
作者单位1.Chinese Acad Sci, Shanghai Inst Appl Phys, Res Ctr Radiopharmaceut, Shanghai 201800, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China
4.Univ Sci & Technol China, Sch Life Sci, Dept Neurobiol, Hefei 230027, Anhui, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Ming-Qiang,Yin, Duan-Zhi,Qiao, Jin-Ping,et al. Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for beta-amyloid plaques in alzheimer's disease[J]. Journal of fluorine chemistry,2008,129(3):210-216.
APA Zheng, Ming-Qiang,Yin, Duan-Zhi,Qiao, Jin-Ping,Zhang, Lan,&Wang, Yong-Xian.(2008).Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for beta-amyloid plaques in alzheimer's disease.Journal of fluorine chemistry,129(3),210-216.
MLA Zheng, Ming-Qiang,et al."Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for beta-amyloid plaques in alzheimer's disease".Journal of fluorine chemistry 129.3(2008):210-216.

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来源:中国科学院大学

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