Sba-15 tablet coated with hpmcp for ph-sensitive drug release system
文献类型：期刊论文
| 作者 | Xu Wu-Jun1,2; Gao Qing1,2; Xu Yao1; Wu Dong1; Sun Yu-Han1 |
| 刊名 | Acta chimica sinica
 |
| 出版日期 | 2008-07-28 |
| 卷号 | 66期号:14页码:1658-1662 |
| 关键词 | Mesoporous material Ph-sensitive Drug release |
| ISSN号 | 0567-7351 |
| 通讯作者 | Xu wu-jun() |
| 英文摘要 | A novel ph-sensitive drug release system was fabricated by coating hydroxypropyl methylcellulose phthalate (hpmcp) on a drug-loaded sba-15 tablet. two kinds of release media, including simulated gastric fluid (sgf, ph=1.2) and simulated intestinal fluid (sif, ph=7.5), were used to study the different drug release behavior of the system sba-15/hpmcp. in sgf, due to the compact hpmcp coating on the sba-15 tablet, the coating material could effectively delay the release rate of famotidine (famo). but in sif, because hpmcp could be quickly dissolved into the release medium, no obvious effect of the coating material on the drug delivery rate was found. therefore, this novel system would have a potential application to targeting intestinal drug release. |
| WOS关键词 | MESOPOROUS SILICA ; DELIVERY-SYSTEM ; MCM-41 |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000258702400010 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2386626 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xu Wu-Jun |
| 作者单位 | 1.Chinese Acad Sci, Inst Cool Chem, State Key Lab Coal Convers, Taiyuan 030001, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu Wu-Jun,Gao Qing,Xu Yao,et al. Sba-15 tablet coated with hpmcp for ph-sensitive drug release system[J]. Acta chimica sinica,2008,66(14):1658-1662. |
| APA | Xu Wu-Jun,Gao Qing,Xu Yao,Wu Dong,&Sun Yu-Han.(2008).Sba-15 tablet coated with hpmcp for ph-sensitive drug release system.Acta chimica sinica,66(14),1658-1662. |
| MLA | Xu Wu-Jun,et al."Sba-15 tablet coated with hpmcp for ph-sensitive drug release system".Acta chimica sinica 66.14(2008):1658-1662. |
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来源：中国科学院大学
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