Transcriptome and proteome analyses of drug interactions with natural products
文献类型：期刊论文
| 作者 | Fang, Hai1,4; Wang, Kankan2; Zhang, Ji1,2,3 |
| 刊名 | Current drug metabolism
 |
| 出版日期 | 2008-12-01 |
| 卷号 | 9期号:10页码:1038-1048 |
| 关键词 | Transcriptome Proteome Component plane presentation integrated self-organizing map Drug synergism Leukemia |
| ISSN号 | 1389-2002 |
| 通讯作者 | Wang, kankan(kankanwang@shsmu.edu.cn) |
| 英文摘要 | Advances in high-throughput technologies to measure genome-scale changes of genes, proteins, and other biomolecular components ('omics') in complex biological systems have dramatically revolutionized biomedical research. however, the benefits of utilizing omics information in drug development have not yet been fully realized. fortunately, the integration of modern systems biology efforts with traditional medicine philosophies, together with integrative bioinformatics, has driven the development of a new drug discovery paradigm. using leukemia as a disease model, therapeutic synergism between drugs and natural products has been investigated by incorporating transcriptomics and proteomics data into a network-like understanding. here, these recent advancements will be discussed in detail, along with perspectives in the field of drug synergism. |
| WOS关键词 | ACUTE PROMYELOCYTIC LEUKEMIA ; TRANS-RETINOIC ACID ; ACUTE MYELOID-LEUKEMIA ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; ACUTE MYELOGENOUS LEUKEMIA ; GENE-EXPRESSION PROFILES ; HEMATOPOIETIC STEM-CELLS ; ARSENIC TRIOXIDE AS2O3 ; MICROARRAY DATA ; IMATINIB MESYLATE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| WOS类目 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000263289500006 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2386635 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Kankan |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Chinese Acad Sci, Shanghai Inst Biol Sci,Inst Hlth Sci,Key Lab Stem, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Inst Hematol, Shanghai 200025, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Sino French Lab Genom & Life Sci, Ruijin Hosp, Shanghai 200025, Peoples R China 4.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Hai,Wang, Kankan,Zhang, Ji. Transcriptome and proteome analyses of drug interactions with natural products[J]. Current drug metabolism,2008,9(10):1038-1048. |
| APA | Fang, Hai,Wang, Kankan,&Zhang, Ji.(2008).Transcriptome and proteome analyses of drug interactions with natural products.Current drug metabolism,9(10),1038-1048. |
| MLA | Fang, Hai,et al."Transcriptome and proteome analyses of drug interactions with natural products".Current drug metabolism 9.10(2008):1038-1048. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。