Transcrintomic and genomic evolution under constant cold in antarctic notothenioid fish
文献类型：期刊论文
| 作者 | Chen, Zuozhou1; Cheng, C. -H. Christina3; Zhang, Junfang1,2; Cao, Lixue1,2; Chen, Lei1; Zhou, Longhai1; Jin, Yudong1; Ye, Hua1,2; Deng, Cheng1,2; Dai, Zhonghua1,2 |
| 刊名 | Proceedings of the national academy of sciences of the united states of america
 |
| 出版日期 | 2008-09-02 |
| 卷号 | 105期号:35页码:12944-12949 |
| ISSN号 | 0027-8424 |
| 关键词 | Cold adaptation Comparative genomics Gene duplication Genome evolution Retrotransposon |
| DOI | 10.1073/pnas.0802432105 |
| 通讯作者 | Chen, liangbiao(lbchen@genetics.ac.cn) |
| 英文摘要 | The antifreeze glycoprotein-fortified antarctic notothenioid fishes comprise the predominant fish suborder in the isolated frigid southern ocean. their ecological success undoubtedly entailed evolutionary acquisition of a full suite of cold-stable functions besides antifreeze protection. prior studies of adaptive changes in these teleost fishes generally examined a single genotype or phenotype. we report here the genome-wide investigations of transcriptional and genomic changes associated with antarctic notothenioid cold adaptation. we sequenced and characterized 33,560 ests from four tissues of the antarctic notothenioid dissostichus mawsoni and derived 3,114 nonredundant protein gene families and their expression profiles. through comparative analyses of same-tissue transcriptome profiles of d. mawsoni and temperate/tropical teleost fishes, we identified 177 notothenioid protein families that were expressed many fold over the latter, indicating cold-related up-regulation. these up-regulated gene families operate in protein biosynthesis, protein folding and degradation, lipid metabolism, antioxidation, antiapoptosis, innate immunity, choriongenesis, and others, all of recognizable functional importance in mitigating stresses in freezing temperatures during notothenioid life histories. we further examined the genomic and evolutionary bases for this expressional up-regulation by comparative genomic hybridization of dna from four pairs of antarctic and basal non-antarctic notothenioids to 10,700 d. mawsoni cdna probes and discovered significant to astounding (3-to >300-fold, p < 0.05) antarctic-specific duplications of 118 protein-coding genes, many of which correspond to the up-regulated gene families. results of our integrative tripartite study strongly suggest that evolution under constant cold has resulted in dramatic genomic expansions of specific protein gene families, augmenting gene expression and gene functions contributing to physiological fitness of antarctic notothenioids in freezing polar conditions. |
| WOS关键词 | OXIDATIVE STRESS ; PROTEIN ; EXPRESSION ; GENES ; TEMPERATURES ; ADAPTATION ; HEMOGLOBIN ; BRAIN ; HOT |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| 出版者 | NATL ACAD SCIENCES |
| WOS记录号 | WOS:000259343000059 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2386741 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Liangbiao |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China 3.Univ Illinois, Dept Anim Biol, Urbana, IL 61801 USA |
| 推荐引用方式 GB/T 7714 | Chen, Zuozhou,Cheng, C. -H. Christina,Zhang, Junfang,et al. Transcrintomic and genomic evolution under constant cold in antarctic notothenioid fish[J]. Proceedings of the national academy of sciences of the united states of america,2008,105(35):12944-12949. |
| APA | Chen, Zuozhou.,Cheng, C. -H. Christina.,Zhang, Junfang.,Cao, Lixue.,Chen, Lei.,...&Chen, Liangbiao.(2008).Transcrintomic and genomic evolution under constant cold in antarctic notothenioid fish.Proceedings of the national academy of sciences of the united states of america,105(35),12944-12949. |
| MLA | Chen, Zuozhou,et al."Transcrintomic and genomic evolution under constant cold in antarctic notothenioid fish".Proceedings of the national academy of sciences of the united states of america 105.35(2008):12944-12949. |
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来源：中国科学院大学
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