Characterization of synthetic heparin-like compounds by negative electrospray ionization fourier transform ion cyclotron resonance mass spectrometry
文献类型：期刊论文
| 作者 | Yan Cun-Yu1,2; Yu Biao3; Liu Shu-Ying1; Cui Meng1; Song Feng-Rui1; Liu Zhi-Qiang1 |
| 刊名 | Chinese journal of analytical chemistry
 |
| 出版日期 | 2008-07-01 |
| 卷号 | 36期号:7页码:910-914 |
| 关键词 | Fourier transform ion cyclotron resonance mass spectrometry(ft-icr-ms) Heparin Electrosray Tandem mass spectrometry Sustained off-resonance irradiation collision induced dissociation |
| ISSN号 | 0253-3820 |
| 通讯作者 | Liu shu-ying(mslab@ciac.jl.cn) |
| 英文摘要 | The full scan and sustained off-resonance it-radiation collision induced dissociation (sori-cid) techniques were employed to study three synthetic heparin-like compounds dh alpha, th alpha and th beta in negative mode using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry (esi fticr-ms). the concentration of stock solution was 10 mu mol/l. the stock solutions were introduced into the ft-icr-ms by syringe pump directly. the structure of sulfamin and sulfonate inside the heparin-like compounds can undergo one or more neutral losses of so, under the soft electrospray ionization condition. the single and double charged pseudomolecular ions presented in the full scan spectra of these compounds. some double charged pseudomolecular ions produced single or double charged fragments, which were deduced from the isotope profile of product ions. the fragmentation pathways of selected precursor ions were assigned by combining the ultrahigh measurement accuracy of their fticr ms data and fragments' charge. the mean errors of the measured mass to charge ratios were less than 3.0 x 10(-6). the results provide references for the analysis of complex heparin-like compounds by mass spectrometry. |
| WOS关键词 | SPECTRA |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000258939700009 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2386993 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu Shu-Ying |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun Ctr Mass Spectrometry, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan Cun-Yu,Yu Biao,Liu Shu-Ying,et al. Characterization of synthetic heparin-like compounds by negative electrospray ionization fourier transform ion cyclotron resonance mass spectrometry[J]. Chinese journal of analytical chemistry,2008,36(7):910-914. |
| APA | Yan Cun-Yu,Yu Biao,Liu Shu-Ying,Cui Meng,Song Feng-Rui,&Liu Zhi-Qiang.(2008).Characterization of synthetic heparin-like compounds by negative electrospray ionization fourier transform ion cyclotron resonance mass spectrometry.Chinese journal of analytical chemistry,36(7),910-914. |
| MLA | Yan Cun-Yu,et al."Characterization of synthetic heparin-like compounds by negative electrospray ionization fourier transform ion cyclotron resonance mass spectrometry".Chinese journal of analytical chemistry 36.7(2008):910-914. |
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来源：中国科学院大学
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