Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction
文献类型：期刊论文
| 作者 | Li, Xuesen2,3; Liu, Zhongbo2,3; Luo, Cheng2; Jia, Haiqun2,3; Sun, Lijuan2; Hou, Bei2; Shen, Weili2; Packer, Lester2,4; Cotman, Carl W.1; Liu, Jiankang1 |
| 刊名 | Free radical biology and medicine
 |
| 出版日期 | 2008-04-01 |
| 卷号 | 44期号:7页码:1465-1474 |
| 关键词 | Mitochondrial complex Protein oxidation Oxidative dna damage Nuclear factor-e2-related factor 2 Glutathione Free radicals |
| ISSN号 | 0891-5849 |
| DOI | 10.1016/j.freeradbiomed.2008.01.004 |
| 通讯作者 | Liu, jiankang(j.liu@uci.edu) |
| 英文摘要 | Alpha-lipoic acid (la) has been widely studied as an agent for preventing and treating various diseases associated with oxidative disruption of mitochondrial functions. to investigate a related mitochondrial antioxidant, we compared the effects of lipoamide (lm), the neutral amide of la, with la for measures of oxidative damage and mitochondrial dysfunction in a human retinal pigment epithelial (rpe) cell line. acrolein, a major component of cigarette smoke and a product of lipid peroxidation, was used to induce oxidative mitochondrial damage in rpe cells. overall, using comparable concentrations, lm was more effective than la at preventing acrolein-induced mitochondrial dysfunction and oxidative stress. relative to la, lm improved atp levels, membrane potentials, and activities of mitochondrial complexes i, ii, and v and dehydrogenases that had been decreased by acrolein exposure. lm reduced acrolein-induced oxidant generation, calcium levels, protein oxidation, and dna damage to a greater degree than la. and, total antioxidant capacity, glutathione content, glutathione s-transferase, and superoxide dismutase activities and expression of nuclear factor-e2-related factor 2 were increased by lm relative to la. these results suggest that lm is a more potent mitochondrial-protective agent and antioxidant than la in protecting rpe from oxidative damage. (c) 2008 elsevier inc. all rights reserved. |
| WOS关键词 | ALPHA-LIPOIC ACID ; AGE-ASSOCIATED MITOCHONDRIAL ; RAT-LIVER MITOCHONDRIA ; ALZHEIMERS-DISEASE ; DIHYDROLIPOIC ACID ; KETOGLUTARATE DEHYDROGENASE ; PYRUVATE-DEHYDROGENASE ; METABOLIC ANTIOXIDANT ; COGNITIVE DYSFUNCTION ; MACULAR DEGENERATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS类目 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000254910600023 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2387115 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Jiankang |
| 作者单位 | 1.Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 4.Univ So Calif, Sch Pharm, Dept Mol Pharmacol & Pharmaceut Sci, Los Angeles, CA 90089 USA |
| 推荐引用方式 GB/T 7714 | Li, Xuesen,Liu, Zhongbo,Luo, Cheng,et al. Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction[J]. Free radical biology and medicine,2008,44(7):1465-1474. |
| APA | Li, Xuesen.,Liu, Zhongbo.,Luo, Cheng.,Jia, Haiqun.,Sun, Lijuan.,...&Liu, Jiankang.(2008).Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction.Free radical biology and medicine,44(7),1465-1474. |
| MLA | Li, Xuesen,et al."Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction".Free radical biology and medicine 44.7(2008):1465-1474. |
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来源：中国科学院大学
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