Rig-i plays a critical role in negatively regulating granulocytic proliferation
文献类型：期刊论文
| 作者 | Zhang, Nan-Nan1,2,3,4; Shen, Shu-Hong1,2,3,4; Jiang, Lin-Jia1,2,3,4; Zhang, Wu1,2,3,4; Zhang, Hong-Xin6; Sun, Yue-Ping6; Li, Xian-Yang1,2,3,4; Huang, Qiu-Hua1,2,3,4; Ge, Bao-Xue1,2,3,4; Chen, Sai-Juan1,2,3,4,5 |
| 刊名 | Proceedings of the national academy of sciences of the united states of america
 |
| 出版日期 | 2008-07-29 |
| 卷号 | 105期号:30页码:10553-10558 |
| 关键词 | Knockout mice Myelopoiesis Ra-inducible gene |
| ISSN号 | 0027-8424 |
| DOI | 10.1073/pnas.0804895105 |
| 通讯作者 | Wang, zhu-gang(zhugangw@shsmu.edu.cn) |
| 英文摘要 | Rig-i has been implicated in innate immunity by sensing intracellular viral rnas and inducing type i ifn production. however, we have found a significant rig-i induction in a biological setting without active viral infection-namely, during ra-induced terminal granulocytic differentiation of acute myeloid leukemias. here, we present evidence that a significant rig-l induction also occurs during normal myelopoiesis and that the disruption of the rig-i gene in mice leads to the development of a progressive myeloproliferative disorder. the initiation of progressive myeloproliferative disorder is mainly due to an intrinsic defect of rig-i-/- myeloid cells, which are characterized by a reduced expression of ifn consensus sequence binding protein, a major regulator of myeloid differentiation. thus, our study reveals a critical regulatory role of rig-i in modulating the generation and differentiation of granulocytes. |
| WOS关键词 | LEUKEMIA-LIKE SYNDROME ; RNA HELICASE ; INNATE IMMUNITY ; ICSBP GENE ; RESPONSES ; MDA-5 ; MICE ; DIFFERENTIATION ; GRANULOPOIESIS ; EXPRESSION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000258211600051 |
| 出版者 | NATL ACAD SCIENCES |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2387500 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Zhu-Gang |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Shanghai 20005, Peoples R China 2.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, State Key Lab Med Genom, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai 200025, Peoples R China 4.Rui Jin Hosp, Shanghai Inst Hematol, Shanghai 200025, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, Shanghai Ctr Syst Biomed, Shanghai 200025, Peoples R China 6.Shanghai Jiao Tong Univ, Fac Basic Med, Dept Med Genet, Shanghai 200240, Peoples R China 7.Shanghai E Inst Model Organisms, Shanghai 200025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Nan-Nan,Shen, Shu-Hong,Jiang, Lin-Jia,et al. Rig-i plays a critical role in negatively regulating granulocytic proliferation[J]. Proceedings of the national academy of sciences of the united states of america,2008,105(30):10553-10558. |
| APA | Zhang, Nan-Nan.,Shen, Shu-Hong.,Jiang, Lin-Jia.,Zhang, Wu.,Zhang, Hong-Xin.,...&Zhu, Jiang.(2008).Rig-i plays a critical role in negatively regulating granulocytic proliferation.Proceedings of the national academy of sciences of the united states of america,105(30),10553-10558. |
| MLA | Zhang, Nan-Nan,et al."Rig-i plays a critical role in negatively regulating granulocytic proliferation".Proceedings of the national academy of sciences of the united states of america 105.30(2008):10553-10558. |
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来源：中国科学院大学
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