中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Rig-i plays a critical role in negatively regulating granulocytic proliferation

文献类型:期刊论文

作者Zhang, Nan-Nan1,2,3,4; Shen, Shu-Hong1,2,3,4; Jiang, Lin-Jia1,2,3,4; Zhang, Wu1,2,3,4; Zhang, Hong-Xin6; Sun, Yue-Ping6; Li, Xian-Yang1,2,3,4; Huang, Qiu-Hua1,2,3,4; Ge, Bao-Xue1,2,3,4; Chen, Sai-Juan1,2,3,4,5
刊名Proceedings of the national academy of sciences of the united states of america
出版日期2008-07-29
卷号105期号:30页码:10553-10558
关键词Knockout mice Myelopoiesis Ra-inducible gene
ISSN号0027-8424
DOI10.1073/pnas.0804895105
通讯作者Wang, zhu-gang(zhugangw@shsmu.edu.cn)
英文摘要Rig-i has been implicated in innate immunity by sensing intracellular viral rnas and inducing type i ifn production. however, we have found a significant rig-i induction in a biological setting without active viral infection-namely, during ra-induced terminal granulocytic differentiation of acute myeloid leukemias. here, we present evidence that a significant rig-l induction also occurs during normal myelopoiesis and that the disruption of the rig-i gene in mice leads to the development of a progressive myeloproliferative disorder. the initiation of progressive myeloproliferative disorder is mainly due to an intrinsic defect of rig-i-/- myeloid cells, which are characterized by a reduced expression of ifn consensus sequence binding protein, a major regulator of myeloid differentiation. thus, our study reveals a critical regulatory role of rig-i in modulating the generation and differentiation of granulocytes.
WOS关键词LEUKEMIA-LIKE SYNDROME ; RNA HELICASE ; INNATE IMMUNITY ; ICSBP GENE ; RESPONSES ; MDA-5 ; MICE ; DIFFERENTIATION ; GRANULOPOIESIS ; EXPRESSION
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
语种英语
WOS记录号WOS:000258211600051
出版者NATL ACAD SCIENCES
URI标识http://www.irgrid.ac.cn/handle/1471x/2387500
专题中国科学院大学
通讯作者Wang, Zhu-Gang
作者单位1.Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Shanghai 20005, Peoples R China
2.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, State Key Lab Med Genom, Shanghai 200025, Peoples R China
3.Chinese Acad Sci, Grad Sch, Shanghai 200025, Peoples R China
4.Rui Jin Hosp, Shanghai Inst Hematol, Shanghai 200025, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, Shanghai Ctr Syst Biomed, Shanghai 200025, Peoples R China
6.Shanghai Jiao Tong Univ, Fac Basic Med, Dept Med Genet, Shanghai 200240, Peoples R China
7.Shanghai E Inst Model Organisms, Shanghai 200025, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Nan-Nan,Shen, Shu-Hong,Jiang, Lin-Jia,et al. Rig-i plays a critical role in negatively regulating granulocytic proliferation[J]. Proceedings of the national academy of sciences of the united states of america,2008,105(30):10553-10558.
APA Zhang, Nan-Nan.,Shen, Shu-Hong.,Jiang, Lin-Jia.,Zhang, Wu.,Zhang, Hong-Xin.,...&Zhu, Jiang.(2008).Rig-i plays a critical role in negatively regulating granulocytic proliferation.Proceedings of the national academy of sciences of the united states of america,105(30),10553-10558.
MLA Zhang, Nan-Nan,et al."Rig-i plays a critical role in negatively regulating granulocytic proliferation".Proceedings of the national academy of sciences of the united states of america 105.30(2008):10553-10558.

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来源:中国科学院大学

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