A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic goto-kakizaki rats
文献类型：期刊论文
| 作者 | Shen, Weili1; Hao, Jiejie1,2; Tian, Chuan1,2; Ren, Jinmin1; Yang, Lu1; Li, Xuesen1,2; Luo, Cheng1; Cotma, Carl W.3; Liu, Jiankang3 |
| 刊名 | Plos one
 |
| 出版日期 | 2008-06-04 |
| 卷号 | 3期号:6页码:10 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0002328 |
| 通讯作者 | Shen, weili() |
| 英文摘要 | Background: recent evidence indicates that insulin resistance in skeletal muscle may be related to reduce mitochondrial number and oxidation capacity. however, it is not known whether increasing mitochondrial number and function improves insulin resistance. in the present study, we investigated the effects of a combination of nutrients on insulin resistance and mitochondrial biogenesis/function in skeletal muscle of type 2 diabetic goto-kakizaki rats. methodology/principal findings: we demonstrated that defect of glucose and lipid metabolism is associated with low mitochondrial content and reduced mitochondrial enzyme activity in skeletal muscle of the diabetic goto-kakizaki rats. the treatment of combination of r-alpha-lipoic acid, acetyl-l-carnitine, nicotinamide, and biotin effectively improved glucose tolerance, decreased the basal insulin secretion and the level of circulating free fatty acid (ffa), and prevented the reduction of mitochondrial biogenesis in skeletal muscle. the nutrients treatment also significantly increased mrna levels of genes involved in lipid metabolism, including peroxisome proliferator-activated receptor-alpha (ppar alpha), peroxisome proliferator activated receptor-delta (ppar delta), and carnitine palmitoyl transferase-1 (mcpt-1) and activity of mitochondrial complex i and ii in skeletal muscle. all of these effects of mitochondrial nutrients are comparable to that of the antidiabetic drug, pioglitazone. in addition, the treatment with nutrients, unlike pioglitazone, did not cause body weight gain. conclusions/significance: these data suggest that a combination of mitochondrial targeting nutrients may improve skeletal mitochondrial dysfunction and exert hypoglycemic effects, without causing weight gain. |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000262614300023 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2387506 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shen, Weili |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA USA |
| 推荐引用方式 GB/T 7714 | Shen, Weili,Hao, Jiejie,Tian, Chuan,et al. A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic goto-kakizaki rats[J]. Plos one,2008,3(6):10. |
| APA | Shen, Weili.,Hao, Jiejie.,Tian, Chuan.,Ren, Jinmin.,Yang, Lu.,...&Liu, Jiankang.(2008).A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic goto-kakizaki rats.Plos one,3(6),10. |
| MLA | Shen, Weili,et al."A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic goto-kakizaki rats".Plos one 3.6(2008):10. |
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来源：中国科学院大学
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