Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants
文献类型：期刊论文
| 作者 | Zhang, Jing1; Xiao, Yuansheng1; Feng, Jiatao1; Wu, Sophia L.2; Xue, Xingya1; Zhang, Xiuli1; Liang, Xinmiao1 |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 52期号:4页码:446-451 |
| 关键词 | Oligo (ethylene glycol) Preparative HPLC Auto-purification Factory Aristolochic acids Aristololactams |
| 产权排序 | 1;1 |
| 通讯作者 | 肖远胜 ; 张秀莉 |
| 英文摘要 | a novel method has been developed for the purification of aristolochic acids and aristololactams compounds from aristolochia plants, a kind of typically toxic traditional chinese medicine. in this method, oligo (ethylene glycol) separation column which has "clustering function" for compounds in tcms was used to produce the fractions containing the compounds with similar structures. a four-channel parallel preparative hplc with c18 separation column was employed to purify the target compounds. the extraction sample of the blending of radix aristolochiae, fructus aristolochiae and caulis aristolochiae manshuriensis was used to develop the method. then, four aristolochic acids and three aristololactams were obtained using this method and the chemical identification was confirmed by q-tof-ms, (1)h nmr and (13)c nmr. thus, this method can deal with more than one traditional chinese medicine simultaneously. additionally, the results demonstrated that this method was an effective way to purify target compounds selectively from tcms. (c) 2010 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | performance liquid-chromatography ; oligo(ethylene glycol) ; stationary-phase ; medicinal-plants ; constituents ; derivatives ; alkaloids ; analogs ; click ; stem |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000276057300004 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/103077]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Germantown Acad, Ft Washington, PA 19034 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Jing,Xiao, Yuansheng,Feng, Jiatao,et al. Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants[J]. journal of pharmaceutical and biomedical analysis,2010,52(4):446-451. |
| APA | Zhang, Jing.,Xiao, Yuansheng.,Feng, Jiatao.,Wu, Sophia L..,Xue, Xingya.,...&Liang, Xinmiao.(2010).Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants.journal of pharmaceutical and biomedical analysis,52(4),446-451. |
| MLA | Zhang, Jing,et al."Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants".journal of pharmaceutical and biomedical analysis 52.4(2010):446-451. |
入库方式： OAI收割
来源：大连化学物理研究所
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