中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants

文献类型:期刊论文

作者Zhang, Jing1; Xiao, Yuansheng1; Feng, Jiatao1; Wu, Sophia L.2; Xue, Xingya1; Zhang, Xiuli1; Liang, Xinmiao1
刊名journal of pharmaceutical and biomedical analysis
出版日期2010-08-01
卷号52期号:4页码:446-451
关键词Oligo (ethylene glycol) Preparative HPLC Auto-purification Factory Aristolochic acids Aristololactams
产权排序1;1
通讯作者肖远胜 ; 张秀莉
英文摘要a novel method has been developed for the purification of aristolochic acids and aristololactams compounds from aristolochia plants, a kind of typically toxic traditional chinese medicine. in this method, oligo (ethylene glycol) separation column which has "clustering function" for compounds in tcms was used to produce the fractions containing the compounds with similar structures. a four-channel parallel preparative hplc with c18 separation column was employed to purify the target compounds. the extraction sample of the blending of radix aristolochiae, fructus aristolochiae and caulis aristolochiae manshuriensis was used to develop the method. then, four aristolochic acids and three aristololactams were obtained using this method and the chemical identification was confirmed by q-tof-ms, (1)h nmr and (13)c nmr. thus, this method can deal with more than one traditional chinese medicine simultaneously. additionally, the results demonstrated that this method was an effective way to purify target compounds selectively from tcms. (c) 2010 elsevier b.v. all rights reserved.
WOS标题词science & technology ; physical sciences ; life sciences & biomedicine
类目[WOS]chemistry, analytical ; pharmacology & pharmacy
研究领域[WOS]chemistry ; pharmacology & pharmacy
关键词[WOS]performance liquid-chromatography ; oligo(ethylene glycol) ; stationary-phase ; medicinal-plants ; constituents ; derivatives ; alkaloids ; analogs ; click ; stem
收录类别SCI
原文出处false
语种英语
WOS记录号WOS:000276057300004
公开日期2010-11-30
源URL[http://159.226.238.44/handle/321008/103077]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Germantown Acad, Ft Washington, PA 19034 USA
推荐引用方式
GB/T 7714
Zhang, Jing,Xiao, Yuansheng,Feng, Jiatao,et al. Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants[J]. journal of pharmaceutical and biomedical analysis,2010,52(4):446-451.
APA Zhang, Jing.,Xiao, Yuansheng.,Feng, Jiatao.,Wu, Sophia L..,Xue, Xingya.,...&Liang, Xinmiao.(2010).Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants.journal of pharmaceutical and biomedical analysis,52(4),446-451.
MLA Zhang, Jing,et al."Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants".journal of pharmaceutical and biomedical analysis 52.4(2010):446-451.

入库方式: OAI收割

来源:大连化学物理研究所

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