Effect of surface wettability and charge on protein adsorption onto implantable alginate-chitosan-alginate microcapsule surfaces
文献类型：期刊论文
| 作者 | Xie, Hong-Guo1,2; Li, Xiao-Xia1,2; Lv, Guo-Jun1; Xie, Wei-Yang1; Zhu, Jing1; Luxbacher, Thomas3; Ma, Ron4; Ma, Xiao-Jun1 |
| 刊名 | journal of biomedical materials research part a
 |
| 出版日期 | 2010-03-15 |
| 卷号 | 92a期号:4页码:1357-1365 |
| 关键词 | microcapsule protein adsorption surface charge fibrinogen gamma globulin |
| 产权排序 | 1;1 |
| 通讯作者 | 马小军 |
| 英文摘要 | alginate-chitosan-alginate (aca) microcapsules have been developed as a device for the transplantation of living cells. however, protein adsorption onto the surface of microcapsules immediately upon their implantation decides their ultimate biocompatibility. in this work, the chemical composition of the aca membranes was determined using x-ray photoelectron spectroscopy (xps). the surface wettability and charge were determined by contact angle and zeta potential measurements, respectively. then, the effects of surface wettability and charge on bovine fibrinogen (fgn) and gamma globulin (igg) adsorption onto aca microcapsules were evaluated. the results showed that aca microcapsules had a hydrophilic membrane. so, the surface wettability of aca microcapsules had little effect on protein adsorption. there was a negative zeta potential of aca microcapsules which varies with the viscosity or g content of alginate used, indicating a varying degree of net negatively charged groups on the surface of aca microcapsules. the amount of adsorbed protein increased with increasing of positive charge. furthermore, the interaction between proteins and aca microcapsules is dominated by electrostatic repulsion at ph 7.4 and that is of electrostatic attraction at ph 6.0. this work could help to explain the bioincompatibility of aca microcapsules and will play an important role in the optimization of the microcapsule design. (c) 2009 wiley periodicals, inc. j biomed mater res 92a: 1357-1365, 2010 |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | engineering, biomedical ; materials science, biomaterials |
| 研究领域[WOS] | engineering ; materials science |
| 关键词[WOS] | solid-surfaces ; oxide nanoparticles ; pll capsules ; biocompatibility ; adhesion ; behavior ; microencapsulation ; transplantation ; conformations ; cells |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000274541500014 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/103103]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Anton Paar GmbH, A-8054 Graz, Austria 4.Anton Paar China, Beijing 100020, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Hong-Guo,Li, Xiao-Xia,Lv, Guo-Jun,et al. Effect of surface wettability and charge on protein adsorption onto implantable alginate-chitosan-alginate microcapsule surfaces[J]. journal of biomedical materials research part a,2010,92a(4):1357-1365. |
| APA | Xie, Hong-Guo.,Li, Xiao-Xia.,Lv, Guo-Jun.,Xie, Wei-Yang.,Zhu, Jing.,...&Ma, Xiao-Jun.(2010).Effect of surface wettability and charge on protein adsorption onto implantable alginate-chitosan-alginate microcapsule surfaces.journal of biomedical materials research part a,92a(4),1357-1365. |
| MLA | Xie, Hong-Guo,et al."Effect of surface wettability and charge on protein adsorption onto implantable alginate-chitosan-alginate microcapsule surfaces".journal of biomedical materials research part a 92a.4(2010):1357-1365. |
入库方式： OAI收割
来源：大连化学物理研究所
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