Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC
文献类型：期刊论文
| 作者 | Yu, Weiting1; Lin, Junzhang1; Liu, Xiudong2; Xie, Hongguo1; Zhao, Wei1; Ma, Xiaojun1 |
| 刊名 | journal of membrane science
 |
| 出版日期 | 2010-01-15 |
| 卷号 | 346期号:2页码:296-301 |
| 关键词 | Alginate-chitosan microcapsule Membrane formation process Quantitative characterization Gel permeation chromatography |
| 产权排序 | 1;1 |
| 通讯作者 | 马小军 |
| 英文摘要 | the semi-permeable membrane of alginate-chitosain (ac) microcapsules has been proven important to control the microcapsule stability and selective substance diffusion rate. therefore, a novel and operable methodology based on gel permeation chromatography (gpc) was established for quantitative characterization of the membrane formation process, so as to provide guidance on performance improvement of ac microcapsules in biomedical applications. not only the molecular weight (m(w)) and its distribution of chitosan can be obtained by gpc, but also the area integral of molecular weight peaks can be linearly correlated to chitosan concentration in certain range. the dynamic membrane formation process was then obtained by quantitatively analyzing reaction amount of chitosam with time, which showed that for chitosan molecules with wide mw distribution, only parts of molecules bind with alginate to form microcapsule membrane. moreover, the contribution of chitosan molecules participating in the membrane formation process was also different. these new findings, therefore, are helpful for adjusting and controlling the membrane formation process and properties of microcapsule membrane. (c) 2009 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; technology ; physical sciences |
| 类目[WOS] | engineering, chemical ; polymer science |
| 研究领域[WOS] | engineering ; polymer science |
| 关键词[WOS] | oligochitosan microcapsules ; exclusion chromatography ; intestinal delivery ; permeability |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000273107400009 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/103105]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Weiting,Lin, Junzhang,Liu, Xiudong,et al. Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC[J]. journal of membrane science,2010,346(2):296-301. |
| APA | Yu, Weiting,Lin, Junzhang,Liu, Xiudong,Xie, Hongguo,Zhao, Wei,&Ma, Xiaojun.(2010).Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC.journal of membrane science,346(2),296-301. |
| MLA | Yu, Weiting,et al."Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC".journal of membrane science 346.2(2010):296-301. |
入库方式： OAI收割
来源：大连化学物理研究所
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