Chronic morphine application is protective against cell death in primary human neurons
文献类型：期刊论文
| 作者 | Cui, Jia; Chen, Qiuyue; Yu, Long-Chuan; Zhang, Yan1 |
| 刊名 | Neuroreport
 |
| 出版日期 | 2008-12-03 |
| 卷号 | 19期号:18页码:1745-1749 |
| 关键词 | Apoptosis Morphine Neurons Protection |
| ISSN号 | 0959-4965 |
| DOI | 10.1097/wnr.0b013e3283186fd7 |
| 通讯作者 | Zhang, yan(yanzhang@pku.edu.cn) |
| 英文摘要 | Morphine addiction has become a long-time, serious medical and social problem. to understand the cellular mechanisms of morphine application and addiction, the effects of chronic morphine treatments were examined in primary cultured human neurons. our results show that, surprisingly, morphine protects cultured human neurons against serum deprivation and staurosporine induced cytotoxicity. morphine downregulates proapoptotic factor bax levels in cultured human neurons. in addition, heat shock protein 70 is also involved in morphine protection. our data suggest that chronic morphine application may be beneficial to stimulate cell survival. neuroreport 19:1745-1749 (c) 2008 wolters kluwer health vertical bar lippincott williams & wilkins. |
| WOS关键词 | INDUCED APOPTOSIS ; PROTEIN ; RAT ; VULNERABILITY ; INVOLVEMENT ; REDUCTION ; TOLERANCE ; MECHANISM ; SURVIVAL ; KINASE |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000261481600001 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2388098 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Yan |
| 作者单位 | 1.Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China 2.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Jia,Chen, Qiuyue,Yu, Long-Chuan,et al. Chronic morphine application is protective against cell death in primary human neurons[J]. Neuroreport,2008,19(18):1745-1749. |
| APA | Cui, Jia,Chen, Qiuyue,Yu, Long-Chuan,&Zhang, Yan.(2008).Chronic morphine application is protective against cell death in primary human neurons.Neuroreport,19(18),1745-1749. |
| MLA | Cui, Jia,et al."Chronic morphine application is protective against cell death in primary human neurons".Neuroreport 19.18(2008):1745-1749. |
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来源：中国科学院大学
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