An ionically crosslinked hydrogel containing vancomycin coating on a porous scaffold for drug delivery and cell culture
文献类型：期刊论文
| 作者 | Zhang, Li Fang1,2; Yang, De Juan1; Chen, He Chun1,2; Sun, Rui1; Xu, Liang1,2; Xiong, Zuo Chun1,2; Govender, Thirumala3; Xiong, Cheng Dong1 |
| 刊名 | International journal of pharmaceutics
 |
| 出版日期 | 2008-04-02 |
| 卷号 | 353期号:1-2页码:74-87 |
| 关键词 | Biodegradable polymers Porous scaffold Alginate hydrogel Coating Controlled release Cell culture |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2007.11.023 |
| 通讯作者 | Xiong, cheng dong(xcd1629@yahoo.com.cn) |
| 英文摘要 | The aim of this study was to prepare and characterize a scaffold with an ionically crosslinked hydrogel coating layer containing a water-soluble drug, vancomycin, via a novel drug loading method for sustained drug delivery and surface modification. the poly(d,l-lactide acid) (pdlla)/biphasic calcium phosphate (bcp) scaffold with a highly inter-connected porous structurewas fabricated by aparticle-leaching/thermally induced phase separation (tips) method. the pre-vacuumized scaffold was immersed into an alginate/vancomycin solution. following impregnation by the solution, the scaffold was removed and immersed in a cacl2 solution for 30 min to allow gelation of the alginate solution. in this way, the drug was not exposed to organic solvents or detrimental temperature conditions and it could avoid loss of drug during the leaching process. the water contact angles of the scaffold surface decreased after being coated with the hydrogel. the in vitro drug release profile showed sustained release properties which were influenced by the alginate concentration and the dissolution medium. a standardized bacterial assay showed that the drug was still active after association with the scaffold by this gentle method of drug loading. the in vitro osteoblast culture experiments confirmed the biocompatibility of the scaffold for attachment and proliferation of osteoblasts. (c) 2007 elsevier b.v. all rights reserved. |
| WOS关键词 | TISSUE-ENGINEERING APPLICATIONS ; INDUCED PHASE-SEPARATION ; IN-VIVO EVALUATION ; POLYMER SCAFFOLDS ; ALGINATE BEADS ; GROWTH-FACTOR ; LACTIDE COMPOSITE ; CALCIUM-PHOSPHATE ; ACID) SCAFFOLDS ; RELEASE |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000255320000011 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2388147 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xiong, Cheng Dong |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Univ KwaZulu Natal, Sch Pharm & Pharmacol, ZA-4000 Durban, South Africa |
| 推荐引用方式 GB/T 7714 | Zhang, Li Fang,Yang, De Juan,Chen, He Chun,et al. An ionically crosslinked hydrogel containing vancomycin coating on a porous scaffold for drug delivery and cell culture[J]. International journal of pharmaceutics,2008,353(1-2):74-87. |
| APA | Zhang, Li Fang.,Yang, De Juan.,Chen, He Chun.,Sun, Rui.,Xu, Liang.,...&Xiong, Cheng Dong.(2008).An ionically crosslinked hydrogel containing vancomycin coating on a porous scaffold for drug delivery and cell culture.International journal of pharmaceutics,353(1-2),74-87. |
| MLA | Zhang, Li Fang,et al."An ionically crosslinked hydrogel containing vancomycin coating on a porous scaffold for drug delivery and cell culture".International journal of pharmaceutics 353.1-2(2008):74-87. |
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来源：中国科学院大学
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