Inhibitory Effects of Curcumenol on Human Liver Cytochrome P450 Enzymes
文献类型：期刊论文
| 作者 | Sun, Dong-Xue1; Fang, Zhong-Ze2,3; Zhang, Yan-Yan2,3; Cao, Yun-Feng1; Yang, Ling2; Yin, Jun1 |
| 刊名 | phytotherapy research
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 24期号:8页码:1213-1216 |
| 关键词 | cytochrome P450 (CYP) curcumenol drug-drug interaction human liver microsomes inhibition enzyme kinetics |
| 产权排序 | 2;2 |
| 通讯作者 | 殷军 |
| 英文摘要 | curcumenol, one of the major components of zedoary turmeric oil, has been widely used to treat cancer and inflammation. as an antibiotic or anticancer drug, curcumenol is highly likely to be used in combination with various synthetic drugs in most cases, thus it is necessary to evaluate potential pharmacokinetic drug-drug interactions induced by curcumenol. in this study, the inhibitory effects of curcumenol on seven cyp isoforms were investigated, and the results demonstrated that only cyp3a4 was strongly inhibited (ic(50) = 12.6 +/- 1.3 mu m). kinetic analysis showed the inhibition type was competitive with k, value of 10.8 mu m. time- and nadph-dependent inhibitions were also investigated to show curcumenol is not a mechanism-based inhibitor. employing these in vitro data and maximum plasma concentration of curcumenol in human predicted from beagle dog's in vivo pharmacokinetic data, the change in auc of victim drugs was predicted to be 0.4%, which suggested that curcumenol may be safely used without inducing metabolic drug-drug interaction through p450 inhibition. nevertheless, due to the limited pharmacokinetic data available for curcumenol in humans, it is still not possible to evaluate its potential clinical effects on human patients from in vitro data. thus, the magnitude of drug-drug interaction (ddi) induced by curcumenol warrants further investigation. copyright (c) 2010 john wiley & sons, ltd. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | drug-drug interactions ; metabolites ; prediction ; extract |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000281006500017 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/103165]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Lab Pharmaceut Resource Discovery, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Dong-Xue,Fang, Zhong-Ze,Zhang, Yan-Yan,et al. Inhibitory Effects of Curcumenol on Human Liver Cytochrome P450 Enzymes[J]. phytotherapy research,2010,24(8):1213-1216. |
| APA | Sun, Dong-Xue,Fang, Zhong-Ze,Zhang, Yan-Yan,Cao, Yun-Feng,Yang, Ling,&Yin, Jun.(2010).Inhibitory Effects of Curcumenol on Human Liver Cytochrome P450 Enzymes.phytotherapy research,24(8),1213-1216. |
| MLA | Sun, Dong-Xue,et al."Inhibitory Effects of Curcumenol on Human Liver Cytochrome P450 Enzymes".phytotherapy research 24.8(2010):1213-1216. |
入库方式： OAI收割
来源：大连化学物理研究所
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