Different physiological roles of serum leptin in the regulation of energy intake and thermogenesis between pregnancy and lactation in primiparous brandt's voles (lasiopodomys brandtii)
文献类型：期刊论文
| 作者 | Zhang, Xue-Ying1,2; Wang, De-Hua1 |
| 刊名 | Comparative biochemistry and physiology c-toxicology & pharmacology
 |
| 出版日期 | 2008-11-01 |
| 卷号 | 148期号:4页码:390-400 |
| 关键词 | Brandt's voles Energy intake Leptin Reproduction Uncoupling protein 1 (ucp1) |
| ISSN号 | 1532-0456 |
| DOI | 10.1016/j.cbpc.2008.01.013 |
| 通讯作者 | Wang, de-hua(wangdh@ioz.ac.cn) |
| 英文摘要 | Reproduction, especially lactation, is associated with major metabolic adaptive changes. in this study, we investigated the metabolic changes and the roles of leptin during different periods of reproduction in primiparous brandt's voles (lasiopodomys brandtii). energy intake, thermogenic capacity and serum leptin levels were examined in non-reproductive, mid pregnant, late pregnant, early lactating and peak lactating, voles. voles increased body mass by nearly 70% during late pregnancy compared to the non-breeding controls. the increase in body mass was mainly due to the increase in body fat mass which increased by 56%, and the growth of the reproductive tissues and digestive organs. lactating voles decreased body fat by nearly 27% at peak lactation compared to the controls, and 53% compared to late pregnant voles. at the same time they increased food intake significantly. uncoupling protein 1 (ucp1) content in brown adipose tissue (bat) decreased significantly at peak lactation. serum leptin increased significantly in the mid pregnancy, at a time when there was no increase in body fat, and remained at this high level in late pregnancy. leptin levels decreased after parturition and reached a nadir at peak lactation. serum leptin was negatively correlated with energy intake during lactation, but not during pregnancy. these data suggest that brandt's voles adjust energy intake, thermogenic capacity and body reserves to match the high energy demands for reproduction. hyperleptinemia, without decreased energy intake suggests a state of leptin resistance during pregnancy, and hypoleptinemia during lactation might act as a signal to stimulate energy intake. (c) 2008 elsevier inc. all rights reserved. |
| WOS关键词 | BROWN ADIPOSE-TISSUE ; SUSTAINED METABOLIC-RATE ; FOOD-INTAKE ; SIGMODON-HISPIDUS ; BODY-COMPOSITION ; GENE-EXPRESSION ; UNCOUPLING PROTEIN-2 ; MICROTUS-BRANDTII ; COLD-ACCLIMATION ; LABORATORY MICE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology |
| WOS类目 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology |
| 语种 | 英语 |
| WOS记录号 | WOS:000261600100012 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2388637 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, De-Hua |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xue-Ying,Wang, De-Hua. Different physiological roles of serum leptin in the regulation of energy intake and thermogenesis between pregnancy and lactation in primiparous brandt's voles (lasiopodomys brandtii)[J]. Comparative biochemistry and physiology c-toxicology & pharmacology,2008,148(4):390-400. |
| APA | Zhang, Xue-Ying,&Wang, De-Hua.(2008).Different physiological roles of serum leptin in the regulation of energy intake and thermogenesis between pregnancy and lactation in primiparous brandt's voles (lasiopodomys brandtii).Comparative biochemistry and physiology c-toxicology & pharmacology,148(4),390-400. |
| MLA | Zhang, Xue-Ying,et al."Different physiological roles of serum leptin in the regulation of energy intake and thermogenesis between pregnancy and lactation in primiparous brandt's voles (lasiopodomys brandtii)".Comparative biochemistry and physiology c-toxicology & pharmacology 148.4(2008):390-400. |
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来源：中国科学院大学
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