Synthesis, radiosynthesis and anticancer activity of beta-elemene tricarbonyl rhenium complex
文献类型：期刊论文
| 作者 | Ren Yun-Feng1,2; Cheng Kang-Min1,2; Liu Gui-Feng1,2; Sun Yan-Hong1; Shen Yu-Mei1 |
| 刊名 | Acta chimica sinica
 |
| 出版日期 | 2008-02-28 |
| 卷号 | 66期号:4页码:459-464 |
| 关键词 | Beta-elemene Tricarbonyl rhenium Re-188 Radiosynthesis Anticancer activity |
| ISSN号 | 0567-7351 |
| 通讯作者 | Ren yun-feng() |
| 英文摘要 | Starting from the traditional chinese medicine beta-elemene, a new kind of beta-elemene tricarbonyl rhenium complex was prepared via halogenation and nucleophilic substitution reactions, followed by reaction with tricarbonyl rhenium. under the similar reaction conditions, the radioactive beta-elemene tricarbonyl rhenium complex was synthesized. all the compounds were characterized by ir, h-1 nmr, hrms, hplc or elemental analysis. the anticancer activity of the target compound was observed in hela and llc lines in vitro. the beta-elemene tricarbonyl rhenium complex provides the possibility to explore the anticancer mechanism of beta-elemene and furthermore find a new kind of radiopharmaccuticals on basis of beta-elemene. |
| WOS关键词 | CELL-GROWTH ; MTOR ; DERIVATIVES |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000254396700011 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2388699 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ren Yun-Feng |
| 作者单位 | 1.Acad Sinica, Shanghai Inst Appl Phys, Radiopharmaceut Ctr, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren Yun-Feng,Cheng Kang-Min,Liu Gui-Feng,et al. Synthesis, radiosynthesis and anticancer activity of beta-elemene tricarbonyl rhenium complex[J]. Acta chimica sinica,2008,66(4):459-464. |
| APA | Ren Yun-Feng,Cheng Kang-Min,Liu Gui-Feng,Sun Yan-Hong,&Shen Yu-Mei.(2008).Synthesis, radiosynthesis and anticancer activity of beta-elemene tricarbonyl rhenium complex.Acta chimica sinica,66(4),459-464. |
| MLA | Ren Yun-Feng,et al."Synthesis, radiosynthesis and anticancer activity of beta-elemene tricarbonyl rhenium complex".Acta chimica sinica 66.4(2008):459-464. |
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来源：中国科学院大学
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