中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Roles of microtubules and microfilaments in spindle movements during rat oocyte meiosis

文献类型:期刊论文

作者Al, Jun-Shu1,2; Wang, Qiang1,2; Li, Mo1,2; Shi, Li-Hong1,2; Ola, Safiriyu Idowu1,3; Xiong, Bo1,2; Yin, Shen1,2; Chen, Da-Yuan1; Sun, Qing-Yuan1
刊名Journal of reproduction and development
出版日期2008-10-01
卷号54期号:5页码:391-396
关键词Microfilaments Microtubules Oocyte Rat Spindle migration Spindle rotation
ISSN号0916-8818
通讯作者Sun, qing-yuan(sunqy@ioz.ac.cn)
英文摘要Spindle movements, including spindle migration from the center to the cortex of oocytes during first meiosis and spindle rotation during second meiosis, are required for asymmetric meiotic divisions in many species. however, little is currently known in relation to the rat oocyte. to explore how spindles move and the mechanism controlling spindle movements in rat oocytes, we observed the spindle dynamics during the two meiotic divisions in the rat oocyte by confocal microscopy. drugs that depolymerize microtubules or microfilaments were employed to further determine the roles of these two cytoskeletons in spindle movements. the results showed that peripheral spindle migration took place during first meiosis and spindle rotation took place during second meiosis in the rat oocytes. microfilament inhibitor inhibited both spindle migration and spindle rotation, and depolymerization of microtubules inhibited spindle rotation. severe depolymerization of microtubules inhibited spindle migration, while migration was achieved by partial but not complete depolymerization of microtubules. we thus conclude that microfilaments are important for both spindle
WOS关键词POLAR BODY FORMATION ; CAENORHABDITIS-ELEGANS ; MEIOTIC SPINDLE ; MOUSE OOCYTES ; NUCLEAR-MOVEMENT ; MITOTIC SPINDLE ; XENOPUS-OOCYTES ; CYTOCHALASIN-B ; MATURATION ; CHROMOSOMES
WOS研究方向Agriculture ; Reproductive Biology
WOS类目Agriculture, Dairy & Animal Science ; Reproductive Biology
语种英语
WOS记录号WOS:000260519200015
出版者SOCIETY REPRODUCTION & DEVELOPMENT-SRD
URI标识http://www.irgrid.ac.cn/handle/1471x/2388904
专题中国科学院大学
通讯作者Sun, Qing-Yuan
作者单位1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
3.Obafemi Awolowo Univ, Dept Anim Sci, Ife, Nigeria
推荐引用方式
GB/T 7714
Al, Jun-Shu,Wang, Qiang,Li, Mo,et al. Roles of microtubules and microfilaments in spindle movements during rat oocyte meiosis[J]. Journal of reproduction and development,2008,54(5):391-396.
APA Al, Jun-Shu.,Wang, Qiang.,Li, Mo.,Shi, Li-Hong.,Ola, Safiriyu Idowu.,...&Sun, Qing-Yuan.(2008).Roles of microtubules and microfilaments in spindle movements during rat oocyte meiosis.Journal of reproduction and development,54(5),391-396.
MLA Al, Jun-Shu,et al."Roles of microtubules and microfilaments in spindle movements during rat oocyte meiosis".Journal of reproduction and development 54.5(2008):391-396.

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来源:中国科学院大学

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