Roles of microtubules and microfilaments in spindle movements during rat oocyte meiosis
文献类型：期刊论文
| 作者 | Al, Jun-Shu1,2; Wang, Qiang1,2; Li, Mo1,2; Shi, Li-Hong1,2; Ola, Safiriyu Idowu1,3; Xiong, Bo1,2; Yin, Shen1,2; Chen, Da-Yuan1; Sun, Qing-Yuan1 |
| 刊名 | Journal of reproduction and development
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 54期号:5页码:391-396 |
| 关键词 | Microfilaments Microtubules Oocyte Rat Spindle migration Spindle rotation |
| ISSN号 | 0916-8818 |
| 通讯作者 | Sun, qing-yuan(sunqy@ioz.ac.cn) |
| 英文摘要 | Spindle movements, including spindle migration from the center to the cortex of oocytes during first meiosis and spindle rotation during second meiosis, are required for asymmetric meiotic divisions in many species. however, little is currently known in relation to the rat oocyte. to explore how spindles move and the mechanism controlling spindle movements in rat oocytes, we observed the spindle dynamics during the two meiotic divisions in the rat oocyte by confocal microscopy. drugs that depolymerize microtubules or microfilaments were employed to further determine the roles of these two cytoskeletons in spindle movements. the results showed that peripheral spindle migration took place during first meiosis and spindle rotation took place during second meiosis in the rat oocytes. microfilament inhibitor inhibited both spindle migration and spindle rotation, and depolymerization of microtubules inhibited spindle rotation. severe depolymerization of microtubules inhibited spindle migration, while migration was achieved by partial but not complete depolymerization of microtubules. we thus conclude that microfilaments are important for both spindle |
| WOS关键词 | POLAR BODY FORMATION ; CAENORHABDITIS-ELEGANS ; MEIOTIC SPINDLE ; MOUSE OOCYTES ; NUCLEAR-MOVEMENT ; MITOTIC SPINDLE ; XENOPUS-OOCYTES ; CYTOCHALASIN-B ; MATURATION ; CHROMOSOMES |
| WOS研究方向 | Agriculture ; Reproductive Biology |
| WOS类目 | Agriculture, Dairy & Animal Science ; Reproductive Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000260519200015 |
| 出版者 | SOCIETY REPRODUCTION & DEVELOPMENT-SRD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2388904 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Sun, Qing-Yuan |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 3.Obafemi Awolowo Univ, Dept Anim Sci, Ife, Nigeria |
| 推荐引用方式 GB/T 7714 | Al, Jun-Shu,Wang, Qiang,Li, Mo,et al. Roles of microtubules and microfilaments in spindle movements during rat oocyte meiosis[J]. Journal of reproduction and development,2008,54(5):391-396. |
| APA | Al, Jun-Shu.,Wang, Qiang.,Li, Mo.,Shi, Li-Hong.,Ola, Safiriyu Idowu.,...&Sun, Qing-Yuan.(2008).Roles of microtubules and microfilaments in spindle movements during rat oocyte meiosis.Journal of reproduction and development,54(5),391-396. |
| MLA | Al, Jun-Shu,et al."Roles of microtubules and microfilaments in spindle movements during rat oocyte meiosis".Journal of reproduction and development 54.5(2008):391-396. |
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来源：中国科学院大学
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