Synthesis of novel thermo- and ph-responsive poly(l-lysine)-based copolymer and its micellization in water
文献类型：期刊论文
| 作者 | Zhao, Changwen1,2; Zhuang, Xiuli1; He, Chaoliang1; Chen, Xuesi1; Jing, Xiabin1 |
| 刊名 | Macromolecular rapid communications
 |
| 出版日期 | 2008-11-19 |
| 卷号 | 29期号:22页码:1810-1816 |
| 关键词 | Hydrophilic polymers Ph responsive Polypeptide Self-assembly Temperature responsive |
| ISSN号 | 1022-1336 |
| DOI | 10.1002/marc.200800494 |
| 通讯作者 | Zhuang, xiuli(zhuangxl@ciac.jl.cn) |
| 英文摘要 | A series of novel temperature and ph responsive block copolymers composed of poly(n-isopropylacrylamide) (pnipam) and poly(l-lysine) (pll) were synthesized. the effect of ph and the length of pll on the lower critical solution temperature (lcst) of pnipam, and the self-assembly of these pll-based copolymers induced by temperature and ph changes were investigated by the cloud point method, dynamic light scattering (dls) and environmental scanning electron microscopy (esem). these pnipam-b-pll copolymers can self-assemble into micelle-like aggregates with pnipam as the hydrophobic block at acidic ph and high temperatures; and at alkaline ph and low hey can self-assemble into temperatures, particles with pll as the hydrophobic block. the copolymers may have potential applications in biotechnological and biomedical areas as drug release carriers. |
| WOS关键词 | HYDROPHILIC BLOCK-COPOLYMERS ; POLY N-ISOPROPYLACRYLAMIDE ; DIBLOCK COPOLYMERS ; DRUG-DELIVERY ; TRIBLOCK COPOLYMER ; POLY(ETHYLENE GLYCOL) ; POLY(L-GLUTAMIC ACID) ; AQUEOUS-SOLUTIONS ; POLYMERIZATION ; VESICLES |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000261544700005 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2388911 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhuang, Xiuli |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Changwen,Zhuang, Xiuli,He, Chaoliang,et al. Synthesis of novel thermo- and ph-responsive poly(l-lysine)-based copolymer and its micellization in water[J]. Macromolecular rapid communications,2008,29(22):1810-1816. |
| APA | Zhao, Changwen,Zhuang, Xiuli,He, Chaoliang,Chen, Xuesi,&Jing, Xiabin.(2008).Synthesis of novel thermo- and ph-responsive poly(l-lysine)-based copolymer and its micellization in water.Macromolecular rapid communications,29(22),1810-1816. |
| MLA | Zhao, Changwen,et al."Synthesis of novel thermo- and ph-responsive poly(l-lysine)-based copolymer and its micellization in water".Macromolecular rapid communications 29.22(2008):1810-1816. |
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来源：中国科学院大学
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