Exploration of gene-gene interaction effects using entropy-based methods
文献类型：期刊论文
| 作者 | Dong, Changzheng1,2,3; Chu, Xun2; Wang, Ying2; Wang, Yi4; Jin, Li4; Shi, Tieliu1; Huang, Wei2,6; Li, Yixue1,5 |
| 刊名 | European journal of human genetics
 |
| 出版日期 | 2008-02-01 |
| 卷号 | 16期号:2页码:229-235 |
| 关键词 | Genetic interaction Epistasis Interaction model Entropy Logistic regression |
| ISSN号 | 1018-4813 |
| DOI | 10.1038/sj.ejhg.5201921 |
| 通讯作者 | Huang, wei(huangwei@chgc.sh.cn) |
| 英文摘要 | Gene-gene interaction may play important roles in complex disease studies, in which interaction effects coupled with single-gene effects are active. many interaction models have been proposed since the beginning of the last century. however, the existing approaches including statistical and data mining methods rarely consider genetic interaction models, which make the interaction results lack biological or genetic meaning. in this study, we developed an entropy-based method integrating two-locus genetic models to explore such interaction effects. we performed our method to simulated and real data for evaluation. simulation results show that this method is effective to detect gene-gene interaction and, furthermore, it is able to identify the best-fit model from various interaction models. moreover, our method, when applied to malaria data, successfully revealed negative epistatic effect between sickle cell anemia and alpha(+)-thalassemia against malaria. |
| WOS关键词 | ENVIRONMENT INTERACTIONS ; QUANTITATIVE TRAITS ; MATHEMATICAL-THEORY ; COMPLEX DISEASES ; EPISTASIS ; ASSOCIATION ; MODELS ; LOCI ; SNPS ; SUSCEPTIBILITY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS类目 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000252426500015 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2389427 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Huang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Bioinformat Ctr, Shanghai, Peoples R China 2.Chinese Natl Human Genome Ctr Shanghai, Shanghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 4.Fudan Univ, Ctr Evolut Biol, MOE Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China 5.Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China 6.Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Shanghai 200025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Changzheng,Chu, Xun,Wang, Ying,et al. Exploration of gene-gene interaction effects using entropy-based methods[J]. European journal of human genetics,2008,16(2):229-235. |
| APA | Dong, Changzheng.,Chu, Xun.,Wang, Ying.,Wang, Yi.,Jin, Li.,...&Li, Yixue.(2008).Exploration of gene-gene interaction effects using entropy-based methods.European journal of human genetics,16(2),229-235. |
| MLA | Dong, Changzheng,et al."Exploration of gene-gene interaction effects using entropy-based methods".European journal of human genetics 16.2(2008):229-235. |
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来源：中国科学院大学
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