Reversal of osteoporotic changes of mineral composition in femurs of diabetic rats by insulin
文献类型：期刊论文
| 作者 | Zhang, Xiaolin; Fei, Yurong; Zhang, Min; Wei, Dan; Li, Ming; Ding, Wenjun; Yang, Jianhong |
| 刊名 | Biological trace element research
 |
| 出版日期 | 2008-03-01 |
| 卷号 | 121期号:3页码:233-242 |
| 关键词 | Element analysis Bone mineral density Insulin Diabetes Icp-aes |
| ISSN号 | 0163-4984 |
| DOI | 10.1007/s12011-007-8043-1 |
| 通讯作者 | Yang, jianhong(yangjh@gucas.ac.cn) |
| 英文摘要 | Insulin plays an important role in bone prevention of diabetic osteoporosis, but little is known about the relation between the bone mineral density (bmd) increase and the change of mineral element content after treated with insulin. to address this problem, male wistar rats were randomly divided into three groups: normal group (n=6), streptozotocin-induced diabetic group (n=5), and streptozotocin-induced diabetic group with insulin treatment (n=5). the femoral bmd was measured by dual energy x-ray absorptiometry, and the element content was determined by inductively coupled plasma atomic emission spectrometry (icp-aes). the results showed that the femoral bmd in diabetic group was significantly lower than that in normal group (p < 0.01) but restored by insulin treatment (p < 0.01 vs diabetic group). icp- aes analysis revealed that the element content of calcium (ca), phosphorous (p), magnesium (mg), strontium (sr), and potassium (k) in diabetic group were remarkably lower than those in normal group (p < 0.01) but only ca, p, and mg content were significantly increased compared with diabetic group (p < 0.05) after insulin treatment. however, no significant differences were observed in element zinc (zn) content among three groups. our findings suggested that the loss of ca, p, mg, sr, and k content accounted for the lower bmd in streptozotocin-induced diabetes rats, insulin treatment could restore bmd by increasing the content of ca, p, and mg. |
| WOS关键词 | POSTMENOPAUSAL WOMEN ; DIETARY MAGNESIUM ; BONE MASS ; STRONTIUM RANELATE ; PHOSPHORUS INTAKE ; SRXRF MICROPROBE ; METABOLIC STATE ; CALCIUM ; MELLITUS ; FRACTURE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS类目 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000253128100006 |
| 出版者 | HUMANA PRESS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2389455 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yang, Jianhong |
| 作者单位 | Chinese Acad Sci, Grad Univ, Sch Life Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaolin,Fei, Yurong,Zhang, Min,et al. Reversal of osteoporotic changes of mineral composition in femurs of diabetic rats by insulin[J]. Biological trace element research,2008,121(3):233-242. |
| APA | Zhang, Xiaolin.,Fei, Yurong.,Zhang, Min.,Wei, Dan.,Li, Ming.,...&Yang, Jianhong.(2008).Reversal of osteoporotic changes of mineral composition in femurs of diabetic rats by insulin.Biological trace element research,121(3),233-242. |
| MLA | Zhang, Xiaolin,et al."Reversal of osteoporotic changes of mineral composition in femurs of diabetic rats by insulin".Biological trace element research 121.3(2008):233-242. |
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来源：中国科学院大学
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