Synthesis, crystallinity and degradation properties of biodegradable poly[(sebacic anhydride)-co-caprolactone] triblock copolymers
文献类型：期刊论文
| 作者 | Mao, Hui1,2; Hao, Jianyuan1,2; Liu, Yan3; Liu, Yu1; Deng, Xianmo1 |
| 刊名 | Polymer international
 |
| 出版日期 | 2008-02-01 |
| 卷号 | 57期号:2页码:316-323 |
| 关键词 | Biodegradable Poly[(sebacic anhydride)-co-caprolactone] Triblock copolymer Degradation properties |
| ISSN号 | 0959-8103 |
| DOI | 10.1002/pi.2349 |
| 通讯作者 | Hao, jianyuan(j.hao@cioc.ac.cn) |
| 英文摘要 | Background: a series of novel biodegradable poly[(sebacic anhydride)-co-caprolactone] (psa-co-pcl) triblock copolymers were prepared by melt condensation of acylated psa and monofunctional hydroxyl-terminated pcl prepolymers. these copolymers could be used as novel drug delivery carriers with expected good drug permeability due to the pcl component. the degradation rate and mode can be modulated by varying the ratio of monomers in the copolymer. results: the homopolymers and copolymers were characterized using h-1 nmr, gel permeation chromatography and differential scanning calorimetry (dsc). h-1 nmr confirmed the formation of triblock copolymers that comprise a middle psa block and two side pcl blocks. dsc revealed that the melting temperature and degree of crystallinity for both sebacic anhydride (sa) and caprolactone (cl) components are strongly composition dependent, implying the hindrance effect of the two components on the crystallinity. in vitro degradation experiments showed that the mass loss is significantly accelerated for samples in base buffer solution and more rapid for the copolymers with a higher sa content. scanning electron microscopy revealed that for sa-rich copolymer, psa(80wt%)-co-pcl, surface erosion dominated the degradation mode of the sample. in contrast, for cl-rich copolymer, psa(20wt%)-co-pcl, a micropore structure developed at a degradation time of 155 h along the edges of the sample, owing to the hydrolysis of sa. conclusion: it is concluded that the rate and mode of degradation of these copolymers can be tuned by varying the composition of the copolymers. (c) 2007 society of chemical industry. |
| WOS关键词 | CONTROLLED DRUG-DELIVERY ; IN-VITRO DEGRADATION ; CO-ETHYLENE GLYCOL) ; BIOERODIBLE POLYANHYDRIDES ; ANHYDRIDE COPOLYMERS ; MELTING BEHAVIOR ; CARRIER MATRICES ; BINARY BLENDS ; SEBACIC ACID ; RELEASE |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000252942200021 |
| 出版者 | JOHN WILEY & SONS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2389597 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Hao, Jianyuan |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat & Engn, Chengdu 610065, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Hui,Hao, Jianyuan,Liu, Yan,et al. Synthesis, crystallinity and degradation properties of biodegradable poly[(sebacic anhydride)-co-caprolactone] triblock copolymers[J]. Polymer international,2008,57(2):316-323. |
| APA | Mao, Hui,Hao, Jianyuan,Liu, Yan,Liu, Yu,&Deng, Xianmo.(2008).Synthesis, crystallinity and degradation properties of biodegradable poly[(sebacic anhydride)-co-caprolactone] triblock copolymers.Polymer international,57(2),316-323. |
| MLA | Mao, Hui,et al."Synthesis, crystallinity and degradation properties of biodegradable poly[(sebacic anhydride)-co-caprolactone] triblock copolymers".Polymer international 57.2(2008):316-323. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。