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Simultaneous determination of pethidine and methadone by capillary electrophoresis with electrochemiluminescence detection of tris(2,2 '-bipyridyl)ruthenium(ii)

文献类型:期刊论文

作者Han, Bingyan2; Du, Yan2; Wang, Erkang2
刊名Microchemical journal
出版日期2008-08-01
卷号89期号:2页码:137-141
关键词Capillary electrophoresis Electrochemiluminescence Pethidine Methadone
ISSN号0026-265X
DOI10.1016/j.microc.2008.01.007
通讯作者Wang, erkang(ekwang@ciac.jl.cn)
英文摘要In this paper, we described a simple and rapid method, capillary electrophoresis with electrochemiluminescence (ce-ecl) detection using tris(2,2'-bipyridyl)ruthenium(ii) (ru(bpy)(3)(2+)), to simultaneously detect pethidine and methadone. analytes were injected to separation capillary of 67.5 cm length (25 mu m i.d., 360 mu m o.d.) by electrokinetic injection for 10 s at 10 kv. under the optimized conditions: ecl detection at 1.20 v, 30 mm sodium phosphate (ph 6.0) as running buffer, separation voltage at 14.0 kv, 5 mm ru(bpy)(3)(2+) with 50 mm sodium phosphate (ph 6.5) in the detection cell, the linear range from 2.0 x 10(-6) to 2.0 x 10(-5) m for pethidine and 5.0 x 10(-6) to 2.0 x 10(-4) m for methadone and detection limits of 0.5 mu m for both of them were achieved (s/n=3). relative standard derivations of the ecl intensity were 2.09% and 6.59% for pethidine and methadone, respectively. (c) 2008 elsevier b.v. all rights reserved.
WOS关键词CHROMATOGRAPHY-MASS SPECTROMETRY ; AMPLIFIED SAMPLE STACKING ; LIQUID-CHROMATOGRAPHY ; BIOLOGICAL-FLUIDS ; HUMAN PLASMA ; ELECTROGENERATED CHEMILUMINESCENCE ; SENSITIVE DETERMINATION ; ZONE-ELECTROPHORESIS ; GAS-CHROMATOGRAPHY ; MAIN METABOLITE
WOS研究方向Chemistry
WOS类目Chemistry, Analytical
语种英语
WOS记录号WOS:000257489900008
出版者ELSEVIER SCIENCE BV
URI标识http://www.irgrid.ac.cn/handle/1471x/2389701
专题中国科学院大学
通讯作者Wang, Erkang
作者单位1.Acad Sinica, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714
Han, Bingyan,Du, Yan,Wang, Erkang. Simultaneous determination of pethidine and methadone by capillary electrophoresis with electrochemiluminescence detection of tris(2,2 '-bipyridyl)ruthenium(ii)[J]. Microchemical journal,2008,89(2):137-141.
APA Han, Bingyan,Du, Yan,&Wang, Erkang.(2008).Simultaneous determination of pethidine and methadone by capillary electrophoresis with electrochemiluminescence detection of tris(2,2 '-bipyridyl)ruthenium(ii).Microchemical journal,89(2),137-141.
MLA Han, Bingyan,et al."Simultaneous determination of pethidine and methadone by capillary electrophoresis with electrochemiluminescence detection of tris(2,2 '-bipyridyl)ruthenium(ii)".Microchemical journal 89.2(2008):137-141.

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来源:中国科学院大学

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