Studies on the biotransformation of 16-o-demethylaconitine and electrospray ionization tandem mass spectrometry
文献类型：期刊论文
| 作者 | Zhao Yu-Feng1,2; Song Feng-Rui1; Wang Xi-Ye1,2; Guo Xin-Hua1; Liu Zhi-Qiang1; Liu Shu-Ying1 |
| 刊名 | Acta chimica sinica
 |
| 出版日期 | 2008-03-14 |
| 卷号 | 66期号:5页码:525-530 |
| 关键词 | 16-o-demethylaconitine Human intestinal bacteria Biotransformation Electrospray ionization mass spectrometry |
| ISSN号 | 0567-7351 |
| 通讯作者 | Zhao yu-feng() |
| 英文摘要 | To study the biotransformation of 16-o-demethylaconitine in human intestine, aconitine was incubated with human intestinal bacteria in vitro. the metabolites of 16-o-demethylaconitine were investigated using ion trap and fourier transform ion cyclotron resonance electrospray ionization tandem mass spectrometry directly. aconitum alkaloids formed protonated molecule [m+h](+) in the positive ion mode. it was found that 16-o-demethylaconitine from biotransformation of aconitine could be further transformed by human intestinal bacteria. there are new metabolites such as mono-ester alkaloids, diester alkaloids and lipo-alkaloids produced by deacetylation, debenzoylation, dehydroxylation, demethylation and more than twenty kinds of esterification in the further transformation process of the 16-o-demethylaconitine. the 16-o-lipodemethylaconitines have been first reported as a metabolite of aconitine by human intestinal bacteria. |
| WOS关键词 | ACONITUM-CARMIECHAELI ; ALKALOIDS ; URINE ; SERUM |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000254396900006 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2389748 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhao Yu-Feng |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao Yu-Feng,Song Feng-Rui,Wang Xi-Ye,et al. Studies on the biotransformation of 16-o-demethylaconitine and electrospray ionization tandem mass spectrometry[J]. Acta chimica sinica,2008,66(5):525-530. |
| APA | Zhao Yu-Feng,Song Feng-Rui,Wang Xi-Ye,Guo Xin-Hua,Liu Zhi-Qiang,&Liu Shu-Ying.(2008).Studies on the biotransformation of 16-o-demethylaconitine and electrospray ionization tandem mass spectrometry.Acta chimica sinica,66(5),525-530. |
| MLA | Zhao Yu-Feng,et al."Studies on the biotransformation of 16-o-demethylaconitine and electrospray ionization tandem mass spectrometry".Acta chimica sinica 66.5(2008):525-530. |
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来源：中国科学院大学
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