Prolonged morphine application modulates bax and hsp70 levels in primary rat neurons
文献类型：期刊论文
| 作者 | Chen, Qiuyue; Cui, Jia; Zhang, Yan1; Yu, Long-Chuan |
| 刊名 | Neuroscience letters
 |
| 出版日期 | 2008-08-29 |
| 卷号 | 441期号:3页码:311-314 |
| 关键词 | Morphine Mu opioid receptors Bax Heat shock protein70 Staurosporine Neurons |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2008.06.067 |
| 通讯作者 | Zhang, yan(yanzhang@pku.edu.cn) |
| 英文摘要 | Morphine has been used for pain treatment with a long history. some data suggest that morphine is toxic to neurons and induces apoptosis, while other evidence shows that morphine could have beneficial effects against cell death. to determine how morphine affects pro-apoptotic protein bax and molecular chaperone hsp70, different concentrations of morphine were examined. our results show that prolonged morphine administration for 5 days at 1 mu m concentration protects against serum deprivation induced cell death in rat primary neurons. morphine treatment decreases bax and hsp70 levels in cultured rat primary neurons, suggesting morphine may have a protective role in staurosporine and serum deprivation induced cytotoxicity. (c) 2008 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | GENE-EXPRESSION ; MESSENGER-RNA ; APOPTOSIS ; PROTEIN ; BRAIN ; NEUROTOXICITY ; TOLERANCE ; MECHANISM ; KINASE |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000258612400015 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2390024 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Yan |
| 作者单位 | 1.Peking Univ, Neurobiol Lab, Beijing 100871, Peoples R China 2.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Qiuyue,Cui, Jia,Zhang, Yan,et al. Prolonged morphine application modulates bax and hsp70 levels in primary rat neurons[J]. Neuroscience letters,2008,441(3):311-314. |
| APA | Chen, Qiuyue,Cui, Jia,Zhang, Yan,&Yu, Long-Chuan.(2008).Prolonged morphine application modulates bax and hsp70 levels in primary rat neurons.Neuroscience letters,441(3),311-314. |
| MLA | Chen, Qiuyue,et al."Prolonged morphine application modulates bax and hsp70 levels in primary rat neurons".Neuroscience letters 441.3(2008):311-314. |
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来源：中国科学院大学
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