The antibacterial efficacy of an aceraceous plant [shantung maple (acer truncatum bunge)] may be related to inhibition of bacterial beta-oxoacyl-acyl carrier protein reductase (fabg)
文献类型：期刊论文
| 作者 | Zhang, Feng1; Luo, Shi-Yun2; Ye, Yan-Bin3; Zhao, Wen-Hua1; Sun, Xu-Guang2; Wang, Zhi-Qun2; Li, Ran2; Sun, Ying-Hui4; Tian, Wei-Xi4; Zhang, Ying-Xia1,5 |
| 刊名 | Biotechnology and applied biochemistry
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 51页码:73-78 |
| 关键词 | Antibacterial activity Enzyme inhibition Beta-oxoacyl-acyl carrier protein reductase (fabg) Shantung maple (acer truncatum bunge) Type ii fatty acid synthase |
| ISSN号 | 0885-4513 |
| DOI | 10.1042/ba20070255 |
| 通讯作者 | Zhang, ying-xia(zhangyue@ccmu.edu.cn) |
| 英文摘要 | Polyphenols, including flavonoids, are the major components of the extracts from aceraceous plants. they possess remarkable antibacterial and antitumour activity. our study focused on whether the inhibition of the bacterial type ii fatty acid synthesis system is the mechanism for the antibacterial effect of the related plant polyphenols. extracts obtained from the fallen leaves of the shantung maple (acer truncatum bunge) using different solvents, and the related pure compound pgg (1,2,3,4,6-penta-o-galloyl-beta-d-glucose), potently inhibited the fabg (beta-oxoacyl-acp reductase) steps in the fatty-acid-elongation cycle with the ic50 values between 0.9 and 7.2 mu g/ml. an ethyl acetate extract appeared to inhibit fabg reductase in a mixed manner with nadph, as did pgg with nadph, demonstrating that they interfered with the binding of the cofactor to the enzyme. gram-positive and gram-negative bacteria and some fungi were used to evaluate the antibacterial abilities of different extract samples. the experiments showed that a higher polyphenol content of the extracts led to a more potent inhibitory capacity against fabg, thus enhancing the antibacterial efficacy. |
| WOS关键词 | SYNTHASE-III FABH ; FATTY-ACID SYNTHASE ; ACER-TRUNCATUM BUNGE ; ESCHERICHIA-COLI ; EPIGALLOCATECHIN GALLATE ; ELONGATION ; MECHANISM |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology |
| WOS类目 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000259834900002 |
| 出版者 | PORTLAND PRESS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2390431 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Ying-Xia |
| 作者单位 | 1.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Biol Chem, Beijing 100069, Peoples R China 2.Capital Med Univ, Beijing Tong Ren Hosp, Beijing Inst Ophthalmol, Dept Ocular Microbiol, Beijing 100005, Peoples R China 3.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Expt Ctr, Beijing 100069, Peoples R China 4.Chinese Acad Sci, Grad Sch, Dept Biol, Beijing 100049, Peoples R China 5.Capital Med Univ, Municipal Key Lab Beijing Regulat Liver Protect &, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Feng,Luo, Shi-Yun,Ye, Yan-Bin,et al. The antibacterial efficacy of an aceraceous plant [shantung maple (acer truncatum bunge)] may be related to inhibition of bacterial beta-oxoacyl-acyl carrier protein reductase (fabg)[J]. Biotechnology and applied biochemistry,2008,51:73-78. |
| APA | Zhang, Feng.,Luo, Shi-Yun.,Ye, Yan-Bin.,Zhao, Wen-Hua.,Sun, Xu-Guang.,...&Zhang, Ying-Xia.(2008).The antibacterial efficacy of an aceraceous plant [shantung maple (acer truncatum bunge)] may be related to inhibition of bacterial beta-oxoacyl-acyl carrier protein reductase (fabg).Biotechnology and applied biochemistry,51,73-78. |
| MLA | Zhang, Feng,et al."The antibacterial efficacy of an aceraceous plant [shantung maple (acer truncatum bunge)] may be related to inhibition of bacterial beta-oxoacyl-acyl carrier protein reductase (fabg)".Biotechnology and applied biochemistry 51(2008):73-78. |
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来源：中国科学院大学
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