Mesoporous magnetic hollow nanoparticles - protein carriers for lysosome escaping and cytosolic delivery
文献类型：期刊论文
| 作者 | Huang, Xinglu1,2; Meng, Xianwei1; Tang, Fangqiong1; Li, Linlin1; Chen, Dong1; Liu, Huiyu1; Zhang, Yanqi1; Ren, Jun1 |
| 刊名 | Nanotechnology
 |
| 出版日期 | 2008-11-05 |
| 卷号 | 19期号:44页码:8 |
| ISSN号 | 0957-4484 |
| DOI | 10.1088/0957-4484/19/44/445101 |
| 通讯作者 | Tang, fangqiong() |
| 英文摘要 | It is important for a controlled release system to determine whether nanoparticles can penetrate cell membranes and deliver protein into the nuclear or cytosolic compartments of cells, and thus function as carriers. here, we prepared different functionalized mesoporous magnetic hollow nanoparticles (mmhs) and chose bovine serum albumin (bsa) as a model protein to detect the intracellular trafficking of mmhs. the results showed that mmhs modified with amino groups (ammhs) were efficient in protein loading and that the loading was dependent on the ph, temperature and ionic strength. furthermore, we found that the ammhs not only transported bsa into the cells but also released the bsa carried into the nuclear or cytosolic compartments of the cells. in addition, the nanoparticles were biocompatible, and the encapsulation of bsa in ammhs did not affect their bioactivity. taken together, ammhs are excellent carriers for releasing protein into the cytosol and nucleus, and they have the potential to be used in a controlled release system. |
| WOS关键词 | CONTROLLED-RELEASE ; DRUG-DELIVERY ; INTRACELLULAR TRAFFICKING ; SILICA NANOPARTICLES ; SYSTEM ; CELLS ; PH ; MACROMOLECULES ; LOCALIZATION ; DEGRADATION |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000259701800001 |
| 出版者 | IOP PUBLISHING LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2390456 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang, Fangqiong |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Lab Controllable Preparat & Applicat Nanomat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xinglu,Meng, Xianwei,Tang, Fangqiong,et al. Mesoporous magnetic hollow nanoparticles - protein carriers for lysosome escaping and cytosolic delivery[J]. Nanotechnology,2008,19(44):8. |
| APA | Huang, Xinglu.,Meng, Xianwei.,Tang, Fangqiong.,Li, Linlin.,Chen, Dong.,...&Ren, Jun.(2008).Mesoporous magnetic hollow nanoparticles - protein carriers for lysosome escaping and cytosolic delivery.Nanotechnology,19(44),8. |
| MLA | Huang, Xinglu,et al."Mesoporous magnetic hollow nanoparticles - protein carriers for lysosome escaping and cytosolic delivery".Nanotechnology 19.44(2008):8. |
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来源：中国科学院大学
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