Microneedle-based drug delivery: studies on delivery parameters and biocompatibility
文献类型：期刊论文
| 作者 | Wu, Yan1,2; Qiu, Yuqin1,2; Zhang, Suohui1,2; Qin, Guangjiong1,2; Gao, Yunhua1 |
| 刊名 | Biomedical microdevices
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 10期号:5页码:601-610 |
| 关键词 | Microneedle Biomems Intradermal drug delivery In vitro Biocompatibility |
| ISSN号 | 1387-2176 |
| DOI | 10.1007/s10544-008-9171-x |
| 通讯作者 | Gao, yunhua(yhgao@mail.ipc.ac.cn) |
| 英文摘要 | There is a significant interest in the application of microneedles in intradermal drug delivery systems. previous studies have demonstrated that skin permeation of drugs can be increased by orders of magnitude with microneedle insertion. in this study, emphasis is placed on the development of low cost, painless intradermal microneedle systems that can enhance the percutaneous drug permeation. microneedles of octagonal pyramidal shape with the length of 150 mu m were employed, and the capabilities of skin permeation enhancement under different delivery conditions were examined. the delivery parameters taken into account included the insertion time and the area of insertion. it was found that when solid microneedle arrays of 150 mu m in length were pierced into human dermatomed skin for 5 to 60 s, microconduits with the depth of 50 to 80 mu m were created to facilitate the percutaneous permeation of drugs. in percutaneous tests, it was demonstrated that the permeability coefficient of calcein ( mw= 622.55) was significantly increased by 104 to 105 times compared to that on intact skin. in terms of biocompatibility, biological evaluation indicated a broad spectrum of safety for the microneedle system. these results suggest that the octagonal pyramidal microneedles can be an effective tool in developing novel intradermal drug delivery system. |
| WOS关键词 | CONVEX CORNER UNDERCUT ; MICROFABRICATED MICRONEEDLES ; SILICON MICRONEEDLES ; GENE DELIVERY ; SKIN |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics |
| WOS类目 | Engineering, Biomedical ; Nanoscience & Nanotechnology |
| 语种 | 英语 |
| WOS记录号 | WOS:000258581700001 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2390484 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gao, Yunhua |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Lab Organ Optoelect Funct Mat & Mol Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yan,Qiu, Yuqin,Zhang, Suohui,et al. Microneedle-based drug delivery: studies on delivery parameters and biocompatibility[J]. Biomedical microdevices,2008,10(5):601-610. |
| APA | Wu, Yan,Qiu, Yuqin,Zhang, Suohui,Qin, Guangjiong,&Gao, Yunhua.(2008).Microneedle-based drug delivery: studies on delivery parameters and biocompatibility.Biomedical microdevices,10(5),601-610. |
| MLA | Wu, Yan,et al."Microneedle-based drug delivery: studies on delivery parameters and biocompatibility".Biomedical microdevices 10.5(2008):601-610. |
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来源：中国科学院大学
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