Preparation of controlled-release microspheres loading protein through solid-in-oil-in-water emulsion method
文献类型：期刊论文
| 作者 | Du Qing1,2; Hu, Jun-Li1,2; Han Ya-Dong1,2; Chen Xue-Si1; Jing Xia-Bin1 |
| 刊名 | Chemical journal of chinese universities-chinese
 |
| 出版日期 | 2008-06-10 |
| 卷号 | 29期号:6页码:1262-1266 |
| 关键词 | Nano-scale sio2 Solid-in-oil-in-water (s/o/w) emulsion method Protein drug Drug controlled release |
| ISSN号 | 0251-0790 |
| 通讯作者 | Chen xue-si(xschen@ciac.jl.cn) |
| 英文摘要 | A novel solid-in-oil-in-water(s/o/w) emulsion method for drug controlled-release system was investigated in this paper. bovine serum albumin(bsa) was used as the model drug. at first, the nanoparticles containing proteins were obtained by adsorbing bsa from the solution onto the surface of nano-scale sio2. then plga microspheres loading the solid nanoparticles were fabricated with the solid-in-oil-in-water emulsion method. compared with the traditional water-in-oll-in-water double emulsion method, this new method has marked advantages, such as improving the percentage of drug in microspheres and the drug entrapment efficiency. more importantly, the activities of protein could be retained better. |
| WOS关键词 | ORGANIC-SOLVENTS ; STABILITY |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000257176300040 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2390488 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen Xue-Si |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Chem & Phys, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du Qing,Hu, Jun-Li,Han Ya-Dong,et al. Preparation of controlled-release microspheres loading protein through solid-in-oil-in-water emulsion method[J]. Chemical journal of chinese universities-chinese,2008,29(6):1262-1266. |
| APA | Du Qing,Hu, Jun-Li,Han Ya-Dong,Chen Xue-Si,&Jing Xia-Bin.(2008).Preparation of controlled-release microspheres loading protein through solid-in-oil-in-water emulsion method.Chemical journal of chinese universities-chinese,29(6),1262-1266. |
| MLA | Du Qing,et al."Preparation of controlled-release microspheres loading protein through solid-in-oil-in-water emulsion method".Chemical journal of chinese universities-chinese 29.6(2008):1262-1266. |
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来源：中国科学院大学
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