Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration
文献类型：期刊论文
| 作者 | Li, Xiaoxia1,2; Wang, Wei1,2; Wei, Guoqiang3; Wang, Guanxiong4; Zhang, Weiguo3; Ma, Xiaojun1,2 |
| 刊名 | biotechnology letters
 |
| 出版日期 | 2010-09-01 |
| 卷号 | 32期号:9页码:1333-1337 |
| 关键词 | Artificial nerve Chitosan FK506 Peripheral nerve regeneration |
| 产权排序 | （1;1） |
| 通讯作者 | 马小军 |
| 英文摘要 | immunophilin ligand fk506 has been treated as adjunct therapy for nerve repair due to its potent neurotrophic and neuroprotective actions. it was hypothesized that fk506 releasing from biodegradable chitosan guide provided better nerve regenerative response than the guide with no fk506. the drug was entrapped in the semi-permeable wall of chitosan guide with the drug-loading of 647 mu g/g. rat sciatic nerve defect model treated with fk506-releasing chitosan guide showed more mature appearance of myelinated fibers 8 weeks after surgery; furthermore, the motor functional reinnervation occurred, the amplitude and velocity of compound muscle action potentials reached 60% and 73% with respect to the normal. thus, fk506-releasing chitosan guide should be acted as a long-lasting delivery device of immunosuppressive and neuroregenerative agent for peripheral nerve repair. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biotechnology & applied microbiology |
| 研究领域[WOS] | biotechnology & applied microbiology |
| 关键词[WOS] | recovery ; injury ; films ; cells ; gaps |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000280892800022 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/103657]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Dalian Med Univ, Dept Orthoped, Affiliated Hosp 1, Dalian 116011, Peoples R China 4.Beijing Univ Chem Technol, Sch Chem Engn, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaoxia,Wang, Wei,Wei, Guoqiang,et al. Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration[J]. biotechnology letters,2010,32(9):1333-1337. |
| APA | Li, Xiaoxia,Wang, Wei,Wei, Guoqiang,Wang, Guanxiong,Zhang, Weiguo,&Ma, Xiaojun.(2010).Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration.biotechnology letters,32(9),1333-1337. |
| MLA | Li, Xiaoxia,et al."Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration".biotechnology letters 32.9(2010):1333-1337. |
入库方式： OAI收割
来源：大连化学物理研究所
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