Biological characters of [f-18]o-fet-pib in a rat model of alzheimer's disease using micro-pet imaging
文献类型：期刊论文
| 作者 | Zheng, Ming-qiang1,5; Yin, Duan-zhi1; Zhang, Lan1; Lei, Bei2; Cheng, Deng-feng1; Cai, Han-cheng1; Han, Yan-jiang1,5; Wu, Ming-xing1,5; Zhang, Hong3; Wang, Jing4 |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 2008-05-01 |
| 卷号 | 29期号:5页码:548-554 |
| 关键词 | Micro-positron emission tomography [f-18]o-fet-pib Alzheimer's disease |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2008.00785.x |
| 通讯作者 | Yin, duan-zhi(comingzeng@yahoo.com.cn) |
| 英文摘要 | Aim: to evaluate whether the newly-synthesized positron emission tomography (pet) tracer, [f-18]2-(4'-(methylamino)phenyl)-6-fluoroethoxy- benzothiazole ([f-18] o-fet-pib), could bind to beta-amyloid aggregates in a rat model of alzheimer's disease (ad) using micro-pet. method: [f-18]o-fet-pib was synthesized and purified by radio hplc. pet imaging was performed with a r4 rodent model scanner in 3 model and 3 control rats. dynamic pet scans were performed for 40 min in each rat following an injection of approximately 37 mbq of [f-18]o-fet-pib. static scans were also performed for 15 min in each rat. pet data were reconstructed by a maximum posteriori probability algorithm. on the coronal pet images, regions of interest were respectively placed on the cortex, hemicerebrum [including the hippocampus and thalamus (ht)], and were guided by a 3-d digital map of the rat brain or the brain images of [f-18]2-deoxy-2-fluoro-jd-glucose ([f-18]fdg) in normal rats. time-activity curves (tac) were obtained for the cerebrum and cerebellum. the activity difference value (adv) between 2 hemicerebrums was also calculated. results: the tac for [f-18]o-fet-pib in the cerebrum or cerebellum peaked early (at approximately 2 min), but washed out a little slowly. in the dynamic and static micro-pet images, increased radioactivity was found in the area of the right ht in the model rats where infused with beta-amyloid (1-40). no distinct difference of radioactivity was found between the right and left ht areas in the control rats. the adv((ht)) was approximately 14.6% in the ad model rats and approximately 4 times greater than that of the control rats (3.9%). conclusion: to our knowledge, this study is the first to evaluate a small molecular pet probe for the p-amyloid deposits in vivo using micro-pet imaging in an ad-injected rat model. the suitable biological characters showed that the tracer had potential to be developed as a probe for detecting beta-amyloid plaques in ad. |
| WOS关键词 | AMYLOID-BETA ; BRAIN ; DEGENERATION ; PROBE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000255419700003 |
| 出版者 | BLACKWELL PUBLISHING |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2390862 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yin, Duan-zhi |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Res Ctr Radiopharmaceut, Shanghai 201800, Peoples R China 2.Fudan Univ, Dept Nucl Med, Huashan Hosp, Shanghai 200040, Peoples R China 3.Zhejiang Univ, Second Affiliated Hosp, Dept Nucl Med, Hangzhou 310009, Peoples R China 4.Zhejiang Calif Int Nanosyst Inst, Hangzhou 310009, Peoples R China 5.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Ming-qiang,Yin, Duan-zhi,Zhang, Lan,et al. Biological characters of [f-18]o-fet-pib in a rat model of alzheimer's disease using micro-pet imaging[J]. Acta pharmacologica sinica,2008,29(5):548-554. |
| APA | Zheng, Ming-qiang.,Yin, Duan-zhi.,Zhang, Lan.,Lei, Bei.,Cheng, Deng-feng.,...&Wang, Jing.(2008).Biological characters of [f-18]o-fet-pib in a rat model of alzheimer's disease using micro-pet imaging.Acta pharmacologica sinica,29(5),548-554. |
| MLA | Zheng, Ming-qiang,et al."Biological characters of [f-18]o-fet-pib in a rat model of alzheimer's disease using micro-pet imaging".Acta pharmacologica sinica 29.5(2008):548-554. |
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来源：中国科学院大学
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