Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bfgf) to fibrin
文献类型：期刊论文
| 作者 | Zhao, Wenxue1,2; Han, Qianqian1,2; Lin, Hang1,2; Gao, Yuan1,2; Sun, Wenjie1,2; Zhao, Yannan1,2; Wang, Bin1,2; Chen, Bing1; Xiao, Zhifeng1; Dai, Jianwu1 |
| 刊名 | Journal of molecular medicine-jmm
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 86期号:10页码:1127-1138 |
| 关键词 | Neovascularization Growth factor Kringle Fibrin Plasma Wound healing |
| ISSN号 | 0946-2716 |
| DOI | 10.1007/s00109-008-0372-9 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Targeted therapy is a new generation of therapeutics, where two critical factors are involved. one is the particular molecular target, and the other is the specific target-binding drug. in this work, the fibrin, a main component of plasma clot at wound sites, was used as the target for human bfgf, aiming to improve therapeutic neovascularization and wound repair. to endow bfgf with fibrin-targeting ability, a fibrin-binding peptide kringle1 (k1), derived from human plasminogen, was fused to human bfgf. the recombinant k1bfgf showed high fibrin and plasma-clot-binding ability. when applied to the wound sites with plasma clots, k1bfgf induced robust neovascularization and improved wound healing. to extend the application of k1bfgf to other cases where no plasma clots exist, we developed a fibrin-scaffold/k1bfgf system. this system could induce localized neovascularization by delivery of k1bfgf in a sustained and site-targeting manner, and provide a microenvironment promoting cell growth and tissue regeneration. in summary, we successfully used the pathologic environment fibrin clot as the target for bfgf, and based on which bfgf was designed into a targeting agent by introduction of a fibrin-binding peptide. this provides a potential approach to improve therapeutic neovascularization and wound repair. |
| WOS关键词 | HUMAN-PLASMINOGEN ; COLLAGEN SCAFFOLDS ; CANCER-THERAPY ; GENE-THERAPY ; BINDING-SITE ; ANGIOGENESIS ; ISCHEMIA ; VASCULARIZATION ; FLAP ; VEGF |
| WOS研究方向 | Genetics & Heredity ; Research & Experimental Medicine |
| WOS类目 | Genetics & Heredity ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000259439400005 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2390871 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mol Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Wenxue,Han, Qianqian,Lin, Hang,et al. Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bfgf) to fibrin[J]. Journal of molecular medicine-jmm,2008,86(10):1127-1138. |
| APA | Zhao, Wenxue.,Han, Qianqian.,Lin, Hang.,Gao, Yuan.,Sun, Wenjie.,...&Dai, Jianwu.(2008).Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bfgf) to fibrin.Journal of molecular medicine-jmm,86(10),1127-1138. |
| MLA | Zhao, Wenxue,et al."Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bfgf) to fibrin".Journal of molecular medicine-jmm 86.10(2008):1127-1138. |
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来源：中国科学院大学
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