Involvement of spinal nitric oxide (no) in rat pain-related behaviors induced by the venom of scorpion buthus martensi karsch
文献类型：期刊论文
| 作者 | Liu, Tong2; Pang, Xue-Yan1; Jiang, Feng1; Ji, Yong-Hua1 |
| 刊名 | Toxicon
 |
| 出版日期 | 2008-07-01 |
| 卷号 | 52期号:1页码:62-71 |
| 关键词 | Bmk venom Nitric oxide Spontaneous pain Thermal hyperalgesia Mechanical hyperalgesia Fos expression |
| ISSN号 | 0041-0101 |
| DOI | 10.1016/j.toxicon.2008.04.171 |
| 通讯作者 | Ji, yong-hua(yhji@staff.shu.edu.cn) |
| 英文摘要 | In the present study, we investigated the role of spinal nitric oxide (no) in rat pain-related behaviors induced by the venom of scorpion buthus martensi karsch (bmk). the results showed that the number of neuronal no synthase (nnos) positive neurons significantly increased in superficial (i-ii), deep (v-vi) dorsal horn laminae and the ventral gray laminae (vii-x), but not in the nucleus proprius (iii and iv) of bilateral l4-l5 lumbar spinal cord after unilateral intraplantar injection of bmk venom from 2 h to 7 d. this increase on the ipsilateral side to bmk venom injection was always greater than that on the contralateral side. western blotting analysis confirmed that spinal nnos expression was significantly up-regulated following bmk venom administration. in addition, intrathecal delivery of n(omega)-nitro-l-arginine methyl ester hydrochloride (l-name; a nos inhibitor) before intraplantar injection of bmk venom by 10 min significantly attenuated spontaneous nociceptive responses and prevented the development of primary thermal hyperalgesia as well as bilateral mechanical hyperalgesia. intrathecal injection of l-name could also partially inhibit bmk venom-induced c-fos expression in lumbar spinal cord at 2 h. thus, the results suggest that spinal no as a critical mediator is involved in various pain-related behaviors and c-fos expression induced by bmk venom in rats. (c) 2008 elsevier ltd. all rights reserved. |
| WOS关键词 | INDUCED THERMAL HYPERALGESIA ; SUBCUTANEOUS INJECTION ; FORMALIN TEST ; BMK VENOM ; PHARMACOLOGICAL INHIBITION ; INTRATHECAL INJECTION ; NOCICEPTIVE RESPONSE ; TRANSMITTER RELEASE ; TITYUS-SERRULATUS ; GENETIC KNOCKOUT |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| WOS类目 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000258816500008 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2390885 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Physiol, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Tong,Pang, Xue-Yan,Jiang, Feng,et al. Involvement of spinal nitric oxide (no) in rat pain-related behaviors induced by the venom of scorpion buthus martensi karsch[J]. Toxicon,2008,52(1):62-71. |
| APA | Liu, Tong,Pang, Xue-Yan,Jiang, Feng,&Ji, Yong-Hua.(2008).Involvement of spinal nitric oxide (no) in rat pain-related behaviors induced by the venom of scorpion buthus martensi karsch.Toxicon,52(1),62-71. |
| MLA | Liu, Tong,et al."Involvement of spinal nitric oxide (no) in rat pain-related behaviors induced by the venom of scorpion buthus martensi karsch".Toxicon 52.1(2008):62-71. |
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来源：中国科学院大学
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