Activation of spinal erk signaling pathway contributes to pain-related responses induced by scorpion buthus martensi karch venom
文献类型：期刊论文
| 作者 | Panga, Xue-Yan1; Liu, Tong2; Jiang, Feng1; Ji, Yong-Hua1 |
| 刊名 | Toxicon
 |
| 出版日期 | 2008-05-01 |
| 卷号 | 51期号:6页码:994-1007 |
| ISSN号 | 0041-0101 |
| 关键词 | Bmk venom Erk C-fos Spontaneous pain Thermal hyperalgesia Mechanical hyperalgesia |
| DOI | 10.1016/j.toxicon.2008.01.005 |
| 通讯作者 | Ji, yong-hua(yhji@server.shcnc.ac.cn) |
| 英文摘要 | It has been demonstrated that spontaneous nociceptive behaviors, cutaneous hyperalgesia and paw edema can be induced by intraplantar injection of scorpion buthus martensi karch (bmk) venom in rats. in the present study, activation of spinal extracellular signal-regulated kinase (erk) signaling pathway and its contribution to pain-related responses induced by scorpion bmk venom were investigated. it was found that erk was activated not only in the superficial layers but also in deep layers of l4-l5 spinal cord dorsal horn, which started at 2min, peaked at 30-60min and almost disappeared at 4 h following intraplantar injection of bmk venom. intrathecal injection of u0126 (0.1, 1.0 and 10 vg), a widely used specific map kinase kinase (mek) inhibitor, suppressed spontaneous nociceptive responses and reduced primary heat hyperalgesia and bilateral mechanical hyperalgesia induced by bmk venom. in addition, bmk venom-induced spinal c-fos expression could be inhibited by u0126 dose-dependently. intrathecal delivery of nmda receptor antagonist (5r, 10s)-(+)-5-methyl-10, 11-dihydro-5h-dibenzo [a,d]-cyclohepten-5-10-imine hydrogen maleate (mk-801) and the non-nmda receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx) could partially inhibit activation of spinal erk induced by bmk venom at 30 min. thus, activation of erk in spinal cord dorsal horn, partially mediated by nmda and non-nmda receptor, potentially contributes to bmk venom-induced pain-related behaviors. (c) 2008 elsevier ltd. all rights reserved. |
| WOS关键词 | CONTRALATERAL HEAT HYPERALGESIA ; DORSAL-HORN NEURONS ; C-FOS EXPRESSION ; LONG-TERM-MEMORY ; NEUROPATHIC PAIN ; SODIUM-CHANNELS ; MAP KINASE ; BMK VENOM ; INTRATHECAL INJECTION ; NOXIOUS-STIMULATION |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| WOS类目 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000256500300006 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2391988 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Grad Sch, Inst Physiol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Panga, Xue-Yan,Liu, Tong,Jiang, Feng,et al. Activation of spinal erk signaling pathway contributes to pain-related responses induced by scorpion buthus martensi karch venom[J]. Toxicon,2008,51(6):994-1007. |
| APA | Panga, Xue-Yan,Liu, Tong,Jiang, Feng,&Ji, Yong-Hua.(2008).Activation of spinal erk signaling pathway contributes to pain-related responses induced by scorpion buthus martensi karch venom.Toxicon,51(6),994-1007. |
| MLA | Panga, Xue-Yan,et al."Activation of spinal erk signaling pathway contributes to pain-related responses induced by scorpion buthus martensi karch venom".Toxicon 51.6(2008):994-1007. |
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来源：中国科学院大学
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