Hydrophilic poly (ethylene glycol) coating on pdlla/bcp bone scaffold for drug delivery and cell culture
文献类型：期刊论文
| 作者 | Zhang, Li Fang1,2; Sun, Rui1; Xu, Liang1,2; Du, Jian1,2; Xiong, Zuo Chun1,2; Chen, He Chun1,2; Xiong, Cheng Dong1 |
| 刊名 | Materials science & engineering c-biomimetic and supramolecular systems
 |
| 出版日期 | 2008 |
| 卷号 | 28期号:1页码:141-149 |
| 关键词 | Porous scaffold Polylactide/biphasic calcium phosphate Poly (ethylene glycol) Microbiological activity Controlled release Cell culture |
| ISSN号 | 0928-4931 |
| DOI | 10.1016/j.msec.2007.01.005 |
| 通讯作者 | Xiong, cheng dong(xcd1633@yahoo.com.cn) |
| 英文摘要 | A well developed porous poly-d-l-lactide (pdlla)/biphasic calcium phosphate (bcp) scaffold was coated with a hydrophilic poly (ethylene glycol) (peg)/vancomycin composite for drug delivery and surface modification. the pdlla/bcp scaffold, obtained by a salt-leaching method, possessed highly inter-connected pores (250-350 mu m) and a high porosity (83.8%). the hydrophilic peg was used to effectively entrap the drug inside the scaffold and to enhance the wettability of the hydrophobic surface of the pdlla/bcp matrix. the scaffold with peg/vancomycin coatings was fabricated by injecting the peg/vancomycin composite solution into the pre-vacuumized scaffold. a standardized bacterial assay showed that the drug was still active after association with the bone scaffold. the in-vitro drug release study of vancomycin showed an initial burst release followed by a slower sustained release. the drug release behavior in vitro was investigated in detail by controlling the composite solution parameters: peg molecular weight and peg concentration. the release profiles showed that an increase in the peg molecular weight and concentration resulted in a slower drug release rate. the water contact angles of the scaffold surface decreased after being coated with peg. the in-vitro osteoblast culture experiment confirmed the biocompatibility of the scaffold for the growth of ostcoblasts. (c) 2007 elsevier b.v. all rights reserved. |
| WOS关键词 | INDUCED PHASE-SEPARATION ; CALCIUM-PHOSPHATE ; GROWTH-FACTOR ; HA/BETA-TCP ; RELEASE ; SURFACE ; PLLA ; COLLAGEN |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000252795000019 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2392420 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xiong, Cheng Dong |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Li Fang,Sun, Rui,Xu, Liang,et al. Hydrophilic poly (ethylene glycol) coating on pdlla/bcp bone scaffold for drug delivery and cell culture[J]. Materials science & engineering c-biomimetic and supramolecular systems,2008,28(1):141-149. |
| APA | Zhang, Li Fang.,Sun, Rui.,Xu, Liang.,Du, Jian.,Xiong, Zuo Chun.,...&Xiong, Cheng Dong.(2008).Hydrophilic poly (ethylene glycol) coating on pdlla/bcp bone scaffold for drug delivery and cell culture.Materials science & engineering c-biomimetic and supramolecular systems,28(1),141-149. |
| MLA | Zhang, Li Fang,et al."Hydrophilic poly (ethylene glycol) coating on pdlla/bcp bone scaffold for drug delivery and cell culture".Materials science & engineering c-biomimetic and supramolecular systems 28.1(2008):141-149. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。