Morphine: a protective or destructive role in neurons?
文献类型：期刊论文
| 作者 | Zhang, Yan1; Chen, Qiuyue; Yu, Long-Chuan |
| 刊名 | Neuroscientist
 |
| 出版日期 | 2008-12-01 |
| 卷号 | 14期号:6页码:561-570 |
| 关键词 | Morphine Protection Toxicity Apoptosis Neurons |
| ISSN号 | 1073-8584 |
| DOI | 10.1177/1073858408314434 |
| 通讯作者 | Zhang, yan(yanzhang@pku.edu.cn) |
| 英文摘要 | Morphine has received intensive research interest for a long time. however, until recently, the protective versus destructive roles of morphine in the neuronal system have not been studied. there is evidence suggesting that morphine induces apoptotic cell death in neuronal and glial cells, whereas controversial studies support a neuroprotective role for morphine. the exact mechanisms for both protective and destructive pathways are not clear and are still under investigation. improved understanding of morphine neuroprotection and neurotoxicity will be helpful to control morphine side effects in medical applications and to identify new targets for potential therapies and prevention strategies to opioid addiction. neuroscientist 14(6): 561-570, 2008. doi: 10.1177/1073858408314434 |
| WOS关键词 | CELLULAR MECHANISMS ; TUMOR-GROWTH ; RAT-BRAIN ; INDUCED CARDIOPROTECTION ; OPIOID ANTAGONISTS ; SIGNALING PATHWAY ; GENE-EXPRESSION ; HEROIN-ADDICTS ; MESSENGER-RNA ; UP-REGULATION |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Clinical Neurology ; Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000261095500011 |
| 出版者 | SAGE PUBLICATIONS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2392656 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Yan |
| 作者单位 | 1.Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China 2.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yan,Chen, Qiuyue,Yu, Long-Chuan. Morphine: a protective or destructive role in neurons?[J]. Neuroscientist,2008,14(6):561-570. |
| APA | Zhang, Yan,Chen, Qiuyue,&Yu, Long-Chuan.(2008).Morphine: a protective or destructive role in neurons?.Neuroscientist,14(6),561-570. |
| MLA | Zhang, Yan,et al."Morphine: a protective or destructive role in neurons?".Neuroscientist 14.6(2008):561-570. |
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来源：中国科学院大学
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