Functional depletion of capsaicin-sensitive primary afferent fibers attenuates rat pain-related behaviors and paw edema induced by the venom of scorpion buthus martensi karch
文献类型：期刊论文
| 作者 | Bai, Zhan-Tao3; Liu, Tong2; Pang, Xue-Yan1; Jiang, Feng1; Cheng, Ming1; Ji, Yong-Hua1 |
| 刊名 | Neuroscience research
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 62期号:2页码:78-85 |
| 关键词 | Bmk venom Resiniferatoxin Capsaicin-sensitive primary afferent fibers Pain Edema |
| ISSN号 | 0168-0102 |
| DOI | 10.1016/j.neures.2008.06.004 |
| 通讯作者 | Ji, yong-hua(yhji@staff.shu.edu.cn) |
| 英文摘要 | The role of capsaicin-sensitive primary afferent fibers in rat pain-related behaviors and paw edema induced by scorpion buthus martensi karch (bmk) venom was investigated in this study. it was found that functional depletion of capsaicin-sensitive primary afferent fibers with a single systemic injection of resiniferatoxin (rtx) dramatically decreased spontaneous nociceptive behaviors, prevented the development of primary mechanical and thermal hyperalgesia as well as mirror-image mechanical hyperalgesia. rtx treatment significantly attenuated bmk venom-induced c-fos expression in all laminaes of bilateral l4-l5 lumbar spinal cord, especially in superficial laminaes. moreover, rtx treatment markedly reduced the early paw edema induced by bmk venom. thus, the results indicate that capsaicin-sensitive primary afferent fibers play a critical role in various pain-related behaviors and paw edema induced by bmk venom in rats. (c) 2008 elsevier ireland ltd and the japan neuroscience society. all rights reserved. |
| WOS关键词 | CONTRALATERAL HEAT HYPERALGESIA ; PRIMARY SENSORY NEURONS ; EPIDERMAL NERVE-FIBERS ; THERMAL HYPERALGESIA ; SPINAL-CORD ; BMK VENOM ; NOCICEPTIVE RESPONSE ; INFLAMMATORY PAIN ; NEUROPATHIC PAIN ; CONSCIOUS RAT |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000260154800002 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2392661 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Grad Sch, Inst Physiol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 3.Yanan Univ, Coll Life Sci, Yanan 716000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Zhan-Tao,Liu, Tong,Pang, Xue-Yan,et al. Functional depletion of capsaicin-sensitive primary afferent fibers attenuates rat pain-related behaviors and paw edema induced by the venom of scorpion buthus martensi karch[J]. Neuroscience research,2008,62(2):78-85. |
| APA | Bai, Zhan-Tao,Liu, Tong,Pang, Xue-Yan,Jiang, Feng,Cheng, Ming,&Ji, Yong-Hua.(2008).Functional depletion of capsaicin-sensitive primary afferent fibers attenuates rat pain-related behaviors and paw edema induced by the venom of scorpion buthus martensi karch.Neuroscience research,62(2),78-85. |
| MLA | Bai, Zhan-Tao,et al."Functional depletion of capsaicin-sensitive primary afferent fibers attenuates rat pain-related behaviors and paw edema induced by the venom of scorpion buthus martensi karch".Neuroscience research 62.2(2008):78-85. |
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来源：中国科学院大学
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