Neural recognition molecules chl1 and nb-3 regulate apical dendrite orientation in the neocortex via ptp alpha
文献类型：期刊论文
| 作者 | Ye, Haihong1; Tan, Yen Ling Jessie1; Ponniah, Sathivel2; Takeda, Yasuo3; Wang, Shi-Qiang4; Schachner, Melitta5,6,7; Watanabe, Kazutada; Pallen, Catherine J.8; Xiao, Zhi-Cheng1,9 |
| 刊名 | Embo journal
 |
| 出版日期 | 2008-01-09 |
| 卷号 | 27期号:1页码:188-200 |
| 关键词 | Adhesion Dendrite development P59fyn |
| ISSN号 | 0261-4189 |
| DOI | 10.1038/sj.emboj.7601939 |
| 通讯作者 | Xiao, zhi-cheng(xiao.zhi.cheng@sgh.com.sg) |
| 英文摘要 | Apical dendrites of pyramidal neurons in the neocortex have a stereotypic orientation that is important for neuronal function. neural recognition molecule close homolog of l1 (chl1) has been shown to regulate oriented growth of apical dendrites in the mouse caudal cortex. here we show that chl1 directly associates with nb-3, a member of the f3/contactin family of neural recognition molecules, and enhances its cell surface expression. similar to chl1, nb-3 exhibits high-caudal to low-rostral expression in the deep layer neurons of the neocortex. nb-3-deficient mice show abnormal apical dendrite projections of deep layer pyramidal neurons in the visual cortex. both chl1 and nb-3 interact with protein tyrosine phosphatase alpha (ptp alpha) and regulate its activity. moreover, deep layer pyramidal neurons of ptp alpha-deficient mice develop misoriented, even inverted, apical dendrites. we propose a signaling complex in which ptpa mediates chl1 and nb-3-regulated apical dendrite projection in the developing caudal cortex. |
| WOS关键词 | TYROSINE-PHOSPHATASE-ALPHA ; SRC-FAMILY KINASES ; CLOSE HOMOLOG ; L1 CHL1 ; CONTACTIN/F3 SUBGROUP ; NEURONAL MIGRATION ; MOTOR COORDINATION ; CEREBRAL-CORTEX ; MICE DEFICIENT ; SEMAPHORIN 3A |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000252230300018 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2393234 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xiao, Zhi-Cheng |
| 作者单位 | 1.Singapore Gen Hosp, Inst Mol & Cell Biol, Dept Clin Res, Singapore 138673, Singapore 2.ASTAR, BRC, Singapore, Singapore 3.Kagoshima Univ, Grad Sch Med & Dental Sci, Dept Clin Pharm & Pharmacol, Kagoshima 890, Japan 4.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China 5.Rutgers State Univ, Keck Ctr Collaborat Neurosci, Piscataway, NJ USA 6.Rutgers State Univ, Dept Cell Biol & Neurosci, Piscataway, NJ USA 7.Dalian Med Univ, Sino German Ctr Neurosci, Dalian, Peoples R China 8.Univ British Columbia, Dept Pediat Child & Family Res Inst, Vancouver, BC V6T 1W5, Canada 9.Singapore Gen Hosp, Dept Clin Res, Singapore 138673, Singapore |
| 推荐引用方式 GB/T 7714 | Ye, Haihong,Tan, Yen Ling Jessie,Ponniah, Sathivel,et al. Neural recognition molecules chl1 and nb-3 regulate apical dendrite orientation in the neocortex via ptp alpha[J]. Embo journal,2008,27(1):188-200. |
| APA | Ye, Haihong.,Tan, Yen Ling Jessie.,Ponniah, Sathivel.,Takeda, Yasuo.,Wang, Shi-Qiang.,...&Xiao, Zhi-Cheng.(2008).Neural recognition molecules chl1 and nb-3 regulate apical dendrite orientation in the neocortex via ptp alpha.Embo journal,27(1),188-200. |
| MLA | Ye, Haihong,et al."Neural recognition molecules chl1 and nb-3 regulate apical dendrite orientation in the neocortex via ptp alpha".Embo journal 27.1(2008):188-200. |
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来源：中国科学院大学
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